What compounds affect the RAF/MAP kinase cascade pathway?

127 compounds in the BiohacksAI corpus have documented interactions with genes in the RAF/MAP kinase cascade pathway (Reactome ID: R-HSA-5673001). These compounds target 89 genes within this pathway.

What genes are in the RAF/MAP kinase cascade pathway?

The RAF/MAP kinase cascade pathway involves 89 genes. Key genes include: ADRM1, ARAF, ARRB1, BCL2L1, BRAF, CAMK2B, CAMK2D, CHURC1-FNTB, CSK, DUSP5.

RAF/MAP kinase cascade

REACTOME PATHWAY

Reactome: R-HSA-567300189 genes127 compounds

The RAF/MAP kinase cascade pathway (Reactome ID: R-HSA-5673001) involves 89 genes and is affected by 127 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ARAF ARRB1 BCL2L1 BRAF CAMK2B CAMK2D CHURC1-FNTB CSK DUSP5 EGFR ERBB2 ERBB3 ERBB4 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FNTA FNTB FYN GRB2 GRIN1 GRIN2B ICMT IL3 ITGA2B ITGB3+59 more

Compounds Affecting RAF/MAP kinase cascade

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Reserpine	—	297
5	sp600125	—	117
6	Axitinib	—	298
7	Crizotinib	—	298
8	Afatinib	—	297
9	Quercetin	—	300
10	tyrphostin ag 1478	—	4
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	pd98059	—	7
14	Vemurafenib	—	298
15	trametinib	—	296
16	pictilisib	—	25
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
19	withaferin	—	300
20	tyrphostin ag 1295	—	1
21	egcg	—	300
22	ly294002	—	11
23	Sirolimus	—	300
24	Gliotoxin	—	300
25	Lovastatin	—	300
26	Okadaic Acid	—	300
27	plumbagin [Supplementary Concept]	—	300
28	Glutamic Acid	—	297
29	Glutamic Acid	—	300
30	Glycine	—	300
31	pentamidine	—	299
32	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
33	Dextrorphan Dextro form of levorphanol. It acts as	—	300
34	Levorphanol	—	297
35	cycloserine	—	298
36	Aspartic Acid	—	300
37	eliprodil	—	33
38	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
39	D-Aspartic Acid	—	29
40	Ethidium	—	300
41	Dextrothyroxine	—	134
42	Dizocilpine Maleate	—	300
43	Ibotenic Acid	—	300
44	Spermine	—	300
45	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
46	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
47	Genistein	—	300
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	Resveratrol	—	298
50	Tetracycline	—	300

About the RAF/MAP kinase cascade Pathway

The RAF/MAP kinase cascade pathway is catalogued in Reactome (ID: R-HSA-5673001) and involves 89 genes. In the BiohacksAI corpus, 127 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ARAF, ARRB1, BCL2L1, BRAF.