What compounds affect the MAP2K and MAPK activation pathway?

38 compounds in the BiohacksAI corpus have documented interactions with genes in the MAP2K and MAPK activation pathway (Reactome ID: R-HSA-5674135). These compounds target 14 genes within this pathway.

What genes are in the MAP2K and MAPK activation pathway?

The MAP2K and MAPK activation pathway involves 14 genes. Key genes include: ARAF, ARRB1, BRAF, CSK, ITGA2B, ITGB3, MAP2K1, MAP2K2, MAPK1, MAPK3.

MAP2K and MAPK activation

REACTOME PATHWAY

Reactome: R-HSA-567413514 genes38 compounds

The MAP2K and MAPK activation pathway (Reactome ID: R-HSA-5674135) involves 14 genes and is affected by 38 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARAF ARRB1 BRAF CSK ITGA2B ITGB3 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 RAF1 SRC YWHAB

Compounds Affecting MAP2K and MAPK activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Vemurafenib	—	298
4	pd98059	—	7
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	trametinib	—	296
8	Quercetin	—	300
9	Axitinib	—	298
10	plumbagin [Supplementary Concept]	—	300
11	tyrphostin ag 1478	—	4
12	sp600125	—	117
13	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
14	withaferin	—	300
15	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
16	Clotrimazole	—	296
17	fisetin	—	78
18	Progesterone	—	299
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	Benzalkonium Compounds	—	299
21	Calcimycin	—	216
22	daph	—	2
23	Diphenhydramine	—	14
24	ha1004	—	4
25	Lithocholic Acid	—	300
26	Loratadine	—	296
27	trequinsin hydrochloride	—	1
28	Resveratrol	—	298
29	Adenosine Monophosphate Adenine nucleotide containing	—	300
30	Afatinib	—	297
31	Crizotinib	—	298
32	monorden	—	8
33	Niclosamide	—	299
34	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
35	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
36	aniracetam	—	110
37	Nadolol	—	297
38	Nicardipine	—	94

About the MAP2K and MAPK activation Pathway

The MAP2K and MAPK activation pathway is catalogued in Reactome (ID: R-HSA-5674135) and involves 14 genes. In the BiohacksAI corpus, 38 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARAF, ARRB1, BRAF, CSK, ITGA2B.