What genes are in the Constitutive Signaling by AKT1 E17K in Cancer pathway?

The Constitutive Signaling by AKT1 E17K in Cancer pathway involves 15 genes. Key genes include: AKT3, BAD, CASP9, CHUK, CREB1, FOXO3, GSK3A, GSK3B, MAPKAP1, MDM2.

Constitutive Signaling by AKT1 E17K in Cancer

Q: What compounds affect the Constitutive Signaling by AKT1 E17K in Cancer pathway?

127 compounds in the BiohacksAI corpus have documented interactions with genes in the Constitutive Signaling by AKT1 E17K in Cancer pathway (Reactome ID: R-HSA-5674400). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-567440015 genes127 compounds

The Constitutive Signaling by AKT1 E17K in Cancer pathway (Reactome ID: R-HSA-5674400) involves 15 genes and is affected by 127 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BAD CASP9 CHUK CREB1 FOXO3 GSK3A GSK3B MAPKAP1 MDM2 MLST8 MTOR NR4A1 PDPK1 RICTOR

Compounds Affecting Constitutive Signaling by AKT1 E17K in Cancer

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	torin 1	—	10
3	Ku 0063794 [Supplementary Concept]	—	7
4	Ursolic Acid	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	chrysin	—	300
7	Quercetin	—	300
8	ly294002	—	11
9	egcg	—	300
10	alsterpaullone	—	12
11	kenpaullone	—	8
12	Calcimycin	—	216
13	cycloheximide	—	300
14	Niclosamide	—	299
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Chlorhexidine	—	299
18	Ciclopirox	—	88
19	Cladribine	—	297
20	Nisoldipine	—	297
21	Nocodazole Nocodazole is	—	215
22	tyrphostin 9	—	2
23	Methylene Blue	—	200
24	Oxyphenbutazone	—	300
25	Disulfiram	—	297
26	Emetine	—	298
27	Epinephrine	—	299
28	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
29	Sirolimus	—	300
30	Everolimus	—	297
31	indirubin	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Kaempferols	—	300
34	fisetin	—	78
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	Digoxin	—	299
37	Cytarabine	—	297
38	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
39	Tubercidin	—	300
40	Anisomycin	—	247
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Colchicine	—	300
43	colchine	—	2
44	Demecolcine	—	246
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Fluspirilene	—	74
47	gedunin	—	54
48	Hexachlorophene	—	300
49	lidoflazine	—	278
50	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300

About the Constitutive Signaling by AKT1 E17K in Cancer Pathway

The Constitutive Signaling by AKT1 E17K in Cancer pathway is catalogued in Reactome (ID: R-HSA-5674400) and involves 15 genes. In the BiohacksAI corpus, 127 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BAD, CASP9, CHUK, CREB1.