Question 1

What compounds target MTOR?

Accepted Answer

BiohacksAI has identified 27 compounds that interact with MTOR (mechanistic target of rapamycin kinase). Top compounds include: Sirolimus, torin 1, pictilisib, Everolimus, ly294002. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is MTOR (mechanistic target of)?

Accepted Answer

MTOR is mechanistic target of rapamycin kinase. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: P42345. NCBI Gene ID: 2475.

#	Compound	Confidence	Active Assays
1	Sirolimus	3.87	47
2	torin 1	3.26	25
3	pictilisib	2.94	18
4	Everolimus	2.83	16
5	ly294002	2.83	16
6	Ku 0063794 [Supplementary Concept]	2.48	11
7	Rotenone	1.95	6
8	Thapsigargin	1.39	3
9	Wortmannin	1.39	3
10	alpelisib	1.10	2
11	amn082	1.10	2
12	Calcimycin	1.10	2
13	Idarubicin	1.10	2
14	Idazoxan	1.10	2
15	Niclosamide	1.10	2
16	triolimus [Supplementary Concept]	1.10	2
17	tyrphostin 9	1.10	2
18	egcg	0.69	1
19	Ursolic Acid	0.69	1
20	Camptothecin	0.69	1
21	Dequalinium	0.69	1
22	Disulfiram	0.69	1
23	Emetine	0.69	1
24	Epinephrine	0.69	1
25	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	0.69	1
26	Maprotiline	0.69	1
27	Perphenazine	0.69	1

BiohacksAI

MTOR

Compounds Targeting MTOR

About MTOR as a Drug Target