Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Q: What compounds affect the Transcription-Coupled Nucleotide Excision Repair (TC-NER) pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcription-Coupled Nucleotide Excision Repair (TC-NER) pathway (Reactome ID: R-HSA-6781827). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-67818277 genes54 compounds

The Transcription-Coupled Nucleotide Excision Repair (TC-NER) pathway (Reactome ID: R-HSA-6781827) involves 7 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 COPS5 ERCC3 PCNA POLK RBX1 USP7

Compounds Affecting Transcription-Coupled Nucleotide Excision Repair (TC-NER)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	alpha-Linolenic Acid	—	300
4	DEAD-box RNA Helicases	—	169
5	Thioctic Acid	—	298
6	Thioctic Acid	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Ethidium	—	300
9	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
10	Carmine Coloring matter from	—	300
11	Epinephrine	—	299
12	gamma-Linolenic Acid	—	300
13	Levodopa	—	297
14	Masoprocol	—	300
15	piceatannol	—	300
16	Arachidonic Acid	—	245
17	fisetin	—	78
18	candesartan cilexetil [Supplementary Concept]	—	300
19	Cefixime	—	300
20	Daunorubicin	—	298
21	Diiodotyrosine	—	300
22	Idarubicin	—	299
23	Methyldopa	—	297
24	Norepinephrine Precursor of epinephrine that is secreted by	—	298
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	Catechin	—	51
27	plumbagin [Supplementary Concept]	—	300
28	Resveratrol	—	298
29	Rutin	—	300
30	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
31	Anthralin	—	299
32	Aurintricarboxylic Acid	—	184
33	butein	—	158
34	Cefotetan	—	299
35	Cimetidine	—	299
36	Demeclocycline	—	5
37	Dihydroxyphenylalanine	—	300
38	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
39	Catechin	—	300
40	Estramustine	—	300
41	o-Phthalaldehyde	—	300
42	Oxytetracycline	—	300
43	rafoxanide	—	172
44	streptonigrin	—	299
45	Suramin	—	300
46	Sphingosine	—	300
47	celastrol	—	300
48	hydroxyfasudil [Supplementary Concept]	—	11
49	pictilisib	—	25
50	Sorafenib	—	300

About the Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway

The Transcription-Coupled Nucleotide Excision Repair (TC-NER) pathway is catalogued in Reactome (ID: R-HSA-6781827) and involves 7 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, COPS5, ERCC3, PCNA, POLK.