TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Q: What compounds affect the TP53 Regulates Transcription of Genes Involved in Cytochrome C Release pathway?

154 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Transcription of Genes Involved in Cytochrome C Release pathway (Reactome ID: R-HSA-6803204). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68032043 genes154 compounds

The TP53 Regulates Transcription of Genes Involved in Cytochrome C Release pathway (Reactome ID: R-HSA-6803204) involves 3 genes and is affected by 154 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CREBBP TP53

Compounds Affecting TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	Nocodazole Nocodazole is	—	215
3	Colchicine	—	300
4	Ethidium	—	300
5	Ethinyl Estradiol	—	300
6	Hexachlorophene	—	300
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Bortezomib	—	300
10	Rotenone	—	300
11	Azathioprine	—	300
12	Cladribine	—	297
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
15	Cytarabine	—	297
16	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
17	Melphalan	—	300
18	Niclosamide	—	299
19	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
20	Methotrexate	—	289
21	Dactinomycin	—	297
22	Daunorubicin	—	298
23	Disulfiram	—	297
24	Glutaral	—	42
25	Vitamin K 3	—	300
26	Trifluridine	—	295
27	Quercetin	—	300
28	Axitinib	—	298
29	ninhydrin	—	300
30	o-Phthalaldehyde	—	300
31	Razoxane	—	154
32	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
33	plumbagin [Supplementary Concept]	—	300
34	Camptothecin	—	300
35	Reserpine	—	297
36	Genistein	—	300
37	Resveratrol	—	298
38	Ciclopirox	—	88
39	Clofarabine	—	298
40	cycloheximide	—	300
41	daph	—	2
42	Dinitrochlorobenzene	—	300
43	Estramustine	—	300
44	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
45	Loratadine	—	296
46	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
47	Riluzole	—	298
48	Thioinosine Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in	—	242
49	Trabectedin	—	297
50	Vorinostat	—	299

About the TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Pathway

The TP53 Regulates Transcription of Genes Involved in Cytochrome C Release pathway is catalogued in Reactome (ID: R-HSA-6803204) and involves 3 genes. In the BiohacksAI corpus, 154 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CREBBP, TP53.