TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Q: What compounds affect the TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest pathway?

175 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest pathway (Reactome ID: R-HSA-6804114). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68041148 genes175 compounds

The TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest pathway (Reactome ID: R-HSA-6804114) involves 8 genes and is affected by 175 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKA CARM1 CCNB1 CDK1 EP300 PCNA PRMT1 TP53

Compounds Affecting TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	chrysin	—	300
3	sp600125	—	117
4	kenpaullone	—	8
5	Ethidium	—	300
6	Rotenone	—	300
7	Disulfiram	—	297
8	Quercetin	—	300
9	Axitinib	—	298
10	plumbagin [Supplementary Concept]	—	300
11	Clotrimazole	—	296
12	Demeclocycline	—	5
13	Clofibrate	—	299
14	Fenofibrate	—	297
15	Nisoldipine	—	297
16	Sertraline	—	1,000
17	Cinnarizine	—	299
18	Nitrofurantoin	—	297
19	Triiodothyronine	—	300
20	s adenosylhomocysteine	—	300
21	alsterpaullone	—	12
22	indirubin	—	300
23	fisetin	—	78
24	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
25	Sorafenib	—	300
26	Ethinyl Estradiol	—	300
27	Hexachlorophene	—	300
28	Azacitidine	—	298
29	Azacitidine	—	300
30	Methylene Blue	—	200
31	Bortezomib	—	300
32	Azathioprine	—	300
33	Cladribine	—	297
34	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
35	Cytarabine	—	297
36	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
37	Melphalan	—	300
38	Niclosamide	—	299
39	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
40	Methotrexate	—	289
41	Dactinomycin	—	297
42	Daunorubicin	—	298
43	Glutaral	—	42
44	Vitamin K 3	—	300
45	Trifluridine	—	295
46	ninhydrin	—	300
47	o-Phthalaldehyde	—	300
48	Razoxane	—	154
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Camptothecin	—	300

About the TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Pathway

The TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest pathway is catalogued in Reactome (ID: R-HSA-6804114) and involves 8 genes. In the BiohacksAI corpus, 175 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA, CARM1, CCNB1, CDK1, EP300.