What genes are in the Regulation of TP53 Activity through Acetylation pathway?

The Regulation of TP53 Activity through Acetylation pathway involves 7 genes. Key genes include: AKT3, EP300, HDAC1, HDAC2, PIN1, PIP4K2A, TP53.

Regulation of TP53 Activity through Acetylation

Q: What compounds affect the Regulation of TP53 Activity through Acetylation pathway?

173 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of TP53 Activity through Acetylation pathway (Reactome ID: R-HSA-6804758). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-68047587 genes173 compounds

The Regulation of TP53 Activity through Acetylation pathway (Reactome ID: R-HSA-6804758) involves 7 genes and is affected by 173 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 EP300 HDAC1 HDAC2 PIN1 PIP4K2A TP53

Compounds Affecting Regulation of TP53 Activity through Acetylation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Daunorubicin	—	298
3	Camptothecin	—	300
4	Vorinostat	—	299
5	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Disulfiram	—	297
8	plumbagin [Supplementary Concept]	—	300
9	rafoxanide	—	172
10	scriptaid	—	53
11	Valproic Acid	—	296
12	pictilisib	—	25
13	Butyric Acid	—	300
14	Ursolic Acid	—	300
15	Celecoxib	—	295
16	Ethidium	—	300
17	Ethinyl Estradiol	—	300
18	Hexachlorophene	—	300
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Methylene Blue	—	200
22	Rotenone	—	300
23	Azathioprine	—	300
24	Cladribine	—	297
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
27	Cytarabine	—	297
28	Melphalan	—	300
29	Niclosamide	—	299
30	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
31	Methotrexate	—	289
32	Dactinomycin	—	297
33	Glutaral	—	42
34	Vitamin K 3	—	300
35	Trifluridine	—	295
36	Quercetin	—	300
37	Axitinib	—	298
38	ninhydrin	—	300
39	o-Phthalaldehyde	—	300
40	Razoxane	—	154
41	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
42	Reserpine	—	297
43	Genistein	—	300
44	Resveratrol	—	298
45	Ciclopirox	—	88
46	Clofarabine	—	298
47	cycloheximide	—	300
48	daph	—	2
49	Dinitrochlorobenzene	—	300
50	Estramustine	—	300

About the Regulation of TP53 Activity through Acetylation Pathway

The Regulation of TP53 Activity through Acetylation pathway is catalogued in Reactome (ID: R-HSA-6804758) and involves 7 genes. In the BiohacksAI corpus, 173 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, EP300, HDAC1, HDAC2, PIN1.