What genes are in the Cyclin E associated events during G1/S transition pathway?

The Cyclin E associated events during G1/S transition pathway involves 43 genes. Key genes include: ADRM1, AKT3, CCNA1, CCNE2, CDC25A, CDK2, CDK4, CDK7, CUL1, MYC.

Cyclin E associated events during G1/S transition

Q: What compounds affect the Cyclin E associated events during G1/S transition pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Cyclin E associated events during G1/S transition pathway (Reactome ID: R-HSA-69202). These compounds target 43 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-6920243 genes37 compounds

The Cyclin E associated events during G1/S transition pathway (Reactome ID: R-HSA-69202) involves 43 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 CCNA1 CCNE2 CDC25A CDK2 CDK4 CDK7 CUL1 MYC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+13 more

Compounds Affecting Cyclin E associated events during G1/S transition

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	sp600125	—	117
7	indirubin	—	300
8	hydroxyfasudil [Supplementary Concept]	—	11
9	Disulfiram	—	297
10	4-Hydroxybenzoate-3-Monooxygenase	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	chrysin	—	300
13	egcg	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Quercetin	—	300
16	Genistein	—	300
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	Aurintricarboxylic Acid	—	184
19	Methylergonovine	—	14
20	Fluocinonide	—	196
21	Pemoline	—	300
22	Sulfaguanidine	—	255
23	Ursodeoxycholic Acid	—	298
24	Adenosine Triphosphate	—	300
25	candesartan cilexetil [Supplementary Concept]	—	300
26	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
27	ninhydrin	—	300
28	pictilisib	—	25
29	Sorafenib	—	300
30	plumbagin [Supplementary Concept]	—	300
31	Vitamin K 3	—	300
32	Pioglitazone	—	297
33	Harmaline	—	300
34	Danazol	—	298
35	Methysergide	—	300
36	Dasatinib	—	299
37	Vemurafenib	—	298

About the Cyclin E associated events during G1/S transition Pathway

The Cyclin E associated events during G1/S transition pathway is catalogued in Reactome (ID: R-HSA-69202) and involves 43 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, CCNA1, CCNE2, CDC25A.