What genes are in the p53-Independent G1/S DNA Damage Checkpoint pathway?

The p53-Independent G1/S DNA Damage Checkpoint pathway involves 44 genes. Key genes include: ADRM1, CDC25A, CHEK1, CHEK2, CSNK1A1, CSNK1E, CUL1, GSK3B, MAPK11, MAPK14.

p53-Independent G1/S DNA Damage Checkpoint

Q: What compounds affect the p53-Independent G1/S DNA Damage Checkpoint pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the p53-Independent G1/S DNA Damage Checkpoint pathway (Reactome ID: R-HSA-69613). These compounds target 44 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-6961344 genes45 compounds

The p53-Independent G1/S DNA Damage Checkpoint pathway (Reactome ID: R-HSA-69613) involves 44 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CDC25A CHEK1 CHEK2 CSNK1A1 CSNK1E CUL1 GSK3B MAPK11 MAPK14 NEK11 PLK3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4+14 more

Compounds Affecting p53-Independent G1/S DNA Damage Checkpoint

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	Sorafenib	—	300
5	egcg	—	300
6	kenpaullone	—	8
7	Quercetin	—	300
8	Dasatinib	—	299
9	Afatinib	—	297
10	alsterpaullone	—	12
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	chrysin	—	300
15	fisetin	—	78
16	ly294002	—	11
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Anisomycin	—	247
20	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
21	withaferin	—	300
22	ninhydrin	—	300
23	indirubin	—	300
24	Kaempferols	—	300
25	Lithium Chloride	—	300
26	Rutin	—	300
27	Ursolic Acid	—	300
28	Oleanolic Acid	—	300
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
30	Disulfiram	—	297
31	4-Hydroxybenzoate-3-Monooxygenase	—	300
32	Genistein	—	300
33	Celecoxib	—	295
34	tyrphostin ag 1478	—	4
35	pictilisib	—	25
36	hydroxyfasudil [Supplementary Concept]	—	11
37	Lovastatin	—	300
38	candesartan cilexetil [Supplementary Concept]	—	300
39	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
40	plumbagin [Supplementary Concept]	—	300
41	Vitamin K 3	—	300
42	Pioglitazone	—	297
43	Harmaline	—	300
44	Wortmannin	—	300
45	Vemurafenib	—	298

About the p53-Independent G1/S DNA Damage Checkpoint Pathway

The p53-Independent G1/S DNA Damage Checkpoint pathway is catalogued in Reactome (ID: R-HSA-69613) and involves 44 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CDC25A, CHEK1, CHEK2, CSNK1A1.