What genes are in the Cyclin A:Cdk2-associated events at S phase entry pathway?

The Cyclin A:Cdk2-associated events at S phase entry pathway involves 44 genes. Key genes include: ADRM1, AKT3, CCNA1, CCNE2, CDC25A, CDC25B, CDK2, CDK4, CDK7, CUL1.

Cyclin A:Cdk2-associated events at S phase entry

Q: What compounds affect the Cyclin A:Cdk2-associated events at S phase entry pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Cyclin A:Cdk2-associated events at S phase entry pathway (Reactome ID: R-HSA-69656). These compounds target 44 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-6965644 genes42 compounds

The Cyclin A:Cdk2-associated events at S phase entry pathway (Reactome ID: R-HSA-69656) involves 44 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 CCNA1 CCNE2 CDC25A CDC25B CDK2 CDK4 CDK7 CUL1 MYC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5+14 more

Compounds Affecting Cyclin A:Cdk2-associated events at S phase entry

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Vitamin K 3	—	300
7	plumbagin [Supplementary Concept]	—	300
8	Aurintricarboxylic Acid	—	184
9	Methylergonovine	—	14
10	sp600125	—	117
11	indirubin	—	300
12	hydroxyfasudil [Supplementary Concept]	—	11
13	Disulfiram	—	297
14	4-Hydroxybenzoate-3-Monooxygenase	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	chrysin	—	300
17	egcg	—	300
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Quercetin	—	300
20	Genistein	—	300
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
23	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
24	Nadolol	—	297
25	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
26	Oleanolic Acid	—	300
27	Fluocinonide	—	196
28	Pemoline	—	300
29	Sulfaguanidine	—	255
30	Ursodeoxycholic Acid	—	298
31	Adenosine Triphosphate	—	300
32	candesartan cilexetil [Supplementary Concept]	—	300
33	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
34	ninhydrin	—	300
35	pictilisib	—	25
36	Sorafenib	—	300
37	Pioglitazone	—	297
38	Harmaline	—	300
39	Danazol	—	298
40	Methysergide	—	300
41	Dasatinib	—	299
42	Vemurafenib	—	298

About the Cyclin A:Cdk2-associated events at S phase entry Pathway

The Cyclin A:Cdk2-associated events at S phase entry pathway is catalogued in Reactome (ID: R-HSA-69656) and involves 44 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, CCNA1, CCNE2, CDC25A.