What compounds affect the Glycolysis pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Glycolysis pathway (Reactome ID: R-HSA-70171). These compounds target 12 genes within this pathway.

What genes are in the Glycolysis pathway?

The Glycolysis pathway involves 12 genes. Key genes include: GAPDH, GCK, GCKR, HK2, HKDC1, PGAM1, PKLR, PKM, PPP2CA, PRKACA.

Glycolysis

REACTOME PATHWAY

Reactome: R-HSA-7017112 genes46 compounds

The Glycolysis pathway (Reactome ID: R-HSA-70171) involves 12 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GAPDH GCK GCKR HK2 HKDC1 PGAM1 PKLR PKM PPP2CA PRKACA PRKACB PRKACG

Compounds Affecting Glycolysis

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Niclosamide	—	299
3	Suramin	—	300
4	Aurintricarboxylic Acid	—	184
5	Demeclocycline	—	297
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Epinephrine	—	299
9	Berberine	—	300
10	plumbagin [Supplementary Concept]	—	300
11	Vitamin K 3	—	300
12	caffeic acid	—	300
13	Catechin	—	51
14	Rosmarinic Acid	—	300
15	Vitamin K 2	—	300
16	Carbazilquinone	—	48
17	salvin [Supplementary Concept]	—	300
18	Dactinomycin	—	297
19	Dihydroxyphenylalanine	—	300
20	Ergosterol	—	300
21	Ethidium	—	300
22	Fusaric Acid	—	300
23	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
24	Lovastatin	—	300
25	Methyldopa	—	297
26	Norepinephrine Precursor of epinephrine that is secreted by	—	298
27	Oxcarbazepine	—	296
28	Pioglitazone	—	297
29	streptonigrin	—	299
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	fisetin	—	78
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	alphitonin [Supplementary Concept] from	—	300
34	Sirolimus	—	300
35	Spermidine	—	241
36	Catechin	—	300
37	pd98059	—	7
38	Pseudoephedrine	—	298
39	Quercetin	—	300
40	Chlorhexidine	—	299
41	Methylene Blue	—	200
42	alpelisib	—	227
43	Sphingosine	—	300
44	egcg	—	300
45	lonidamine	—	300
46	Okadaic Acid	—	300

About the Glycolysis Pathway

The Glycolysis pathway is catalogued in Reactome (ID: R-HSA-70171) and involves 12 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GAPDH, GCK, GCKR, HK2, HKDC1.