What compounds affect the DNA Damage Bypass pathway?

70 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Damage Bypass pathway (Reactome ID: R-HSA-73893). These compounds target 8 genes within this pathway.

What genes are in the DNA Damage Bypass pathway?

The DNA Damage Bypass pathway involves 8 genes. Key genes include: PCNA, POLH, POLI, POLK, RBX1, USP1, USP10, VCP.

DNA Damage Bypass

REACTOME PATHWAY

Reactome: R-HSA-738938 genes70 compounds

The DNA Damage Bypass pathway (Reactome ID: R-HSA-73893) involves 8 genes and is affected by 70 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PCNA POLH POLI POLK RBX1 USP1 USP10 VCP

Compounds Affecting DNA Damage Bypass

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Ethidium	—	300
4	alpha-Linolenic Acid	—	300
5	Idarubicin	—	299
6	Aurintricarboxylic Acid	—	184
7	streptonigrin	—	299
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	gamma-Linolenic Acid	—	300
10	Levodopa	—	297
11	Masoprocol	—	300
12	piceatannol	—	300
13	candesartan cilexetil [Supplementary Concept]	—	300
14	Cefixime	—	300
15	Diiodotyrosine	—	300
16	Norepinephrine Precursor of epinephrine that is secreted by	—	298
17	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
18	Cefotetan	—	299
19	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
20	Oxytetracycline	—	300
21	Hexachlorophene	—	300
22	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
23	Carmine Coloring matter from	—	300
24	Arachidonic Acid	—	245
25	Daunorubicin	—	298
26	Methyldopa	—	297
27	plumbagin [Supplementary Concept]	—	300
28	Demeclocycline	—	5
29	Catechin	—	300
30	Estramustine	—	300
31	o-Phthalaldehyde	—	300
32	Suramin	—	300
33	Kaempferols	—	300
34	Methotrexate	—	289
35	Adapalene	—	296
36	Epinephrine	—	299
37	fisetin	—	78
38	DEAD-box RNA Helicases	—	169
39	Thioctic Acid	—	298
40	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
41	Catechin	—	51
42	Resveratrol	—	298
43	Rutin	—	300
44	Anthralin	—	299
45	butein	—	158
46	Cimetidine	—	299
47	Dihydroxyphenylalanine	—	300
48	rafoxanide	—	172
49	Thioctic Acid	—	300
50	Cisplatin	—	300

About the DNA Damage Bypass Pathway

The DNA Damage Bypass pathway is catalogued in Reactome (ID: R-HSA-73893) and involves 8 genes. In the BiohacksAI corpus, 70 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, POLH, POLI, POLK, RBX1.