Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACTOME PATHWAYThe Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway (Reactome ID: R-HSA-75035) involves 8 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | alsterpaullone | — | 12 |
| 3 | sp600125 | — | 117 |
| 4 | indirubin | — | 300 |
| 5 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 6 | chrysin | — | 300 |
| 7 | fisetin | — | 78 |
| 8 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 9 | Quercetin | — | 300 |
| 10 | Clofibrate | — | 299 |
| 11 | Fenofibrate | — | 297 |
| 12 | Sertraline | — | 1,000 |
| 13 | Cinnarizine | — | 299 |
| 14 | Clotrimazole | — | 296 |
| 15 | Rotenone | — | 300 |
| 16 | Sorafenib | — | 300 |
| 17 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 18 | Lovastatin | — | 300 |
| 19 | Fluocinonide | — | 196 |
| 20 | Pemoline | — | 300 |
| 21 | Sulfaguanidine | — | 255 |
| 22 | Ursodeoxycholic Acid | — | 298 |
| 23 | Idarubicin | — | 299 |
| 24 | Masoprocol | — | 300 |
About the Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Pathway
The Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway is catalogued in Reactome (ID: R-HSA-75035) and involves 8 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CCNB1, CDK1, CHEK1, CHEK2.