What genes are in the Response to elevated platelet cytosolic Ca2+ pathway?

The Response to elevated platelet cytosolic Ca2+ pathway involves 12 genes. Key genes include: ABCC4, ALB, APP, CFL1, F13A1, F5, HSPA5, ITGA2B, ITGB3, SERPINE1.

Response to elevated platelet cytosolic Ca2+

Q: What compounds affect the Response to elevated platelet cytosolic Ca2+ pathway?

78 compounds in the BiohacksAI corpus have documented interactions with genes in the Response to elevated platelet cytosolic Ca2+ pathway (Reactome ID: R-HSA-76005). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-7600512 genes78 compounds

The Response to elevated platelet cytosolic Ca2+ pathway (Reactome ID: R-HSA-76005) involves 12 genes and is affected by 78 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC4 ALB APP CFL1 F13A1 F5 HSPA5 ITGA2B ITGB3 SERPINE1 SOD1 TUBA4A

Compounds Affecting Response to elevated platelet cytosolic Ca2+

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Catechin	—	300
3	Podophyllotoxin	—	14
4	Hexachlorophene	—	300
5	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
6	Resveratrol	—	298
7	Quercetin	—	300
8	Hesperidin	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Kaempferols	—	300
11	Methylene Blue	—	200
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	caffeic acid	—	300
16	Vitamin	—	295
17	2-Methoxyestradiol	—	300
18	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
19	Cladribine	—	297
20	Digitoxin	—	300
21	Digoxin	—	299
22	Disulfiram	—	297
23	Edetic Acid	—	24
24	Vanillic Acid	—	300
25	Ouabain	—	300
26	Quinic Acid	—	218
27	Retinaldehyde	—	300
28	streptonigrin	—	299
29	Trifluridine	—	295
30	Alprostadil	—	297
31	Dehydroepiandrosterone Sulfate	—	300
32	Rimonabant	—	300
33	amlexanox	—	96
34	Camptothecin	—	300
35	cefaclor	—	299
36	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
37	Cefmetazole	—	300
38	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
39	Cefoxitin	—	300
40	Ceftriaxone	—	299
41	cefuroxime	—	299
42	Cephradine	—	298
43	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
44	Dinoprostone	—	296
45	Doxazosin	—	24
46	Febuxostat	—	297
47	felbinac	—	31
48	Tubocurarine	—	300
49	Warfarin	—	1,000
50	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300

About the Response to elevated platelet cytosolic Ca2+ Pathway

The Response to elevated platelet cytosolic Ca2+ pathway is catalogued in Reactome (ID: R-HSA-76005) and involves 12 genes. In the BiohacksAI corpus, 78 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC4, ALB, APP, CFL1, F13A1.