Interleukin-20 family signaling
REACTOME PATHWAYThe Interleukin-20 family signaling pathway (Reactome ID: R-HSA-8854691) involves 6 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interleukin-20 family signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Methylene Blue | — | 200 |
| 2 | streptonigrin | — | 299 |
| 3 | Methotrexate | — | 289 |
| 4 | Crizotinib | — | 298 |
| 5 | sp600125 | — | 117 |
| 6 | Axitinib | — | 298 |
| 7 | Sorafenib | — | 300 |
| 8 | Azauridine | — | 300 |
| 9 | Cladribine | — | 297 |
| 10 | Dasatinib | — | 299 |
| 11 | 2-Methoxyestradiol | — | 300 |
| 12 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 13 | Azathioprine | — | 300 |
| 14 | Calcitriol | — | 300 |
| 15 | Camptothecin | — | 300 |
| 16 | Cytarabine | — | 297 |
| 17 | dihydrorotenone | — | 13 |
| 18 | Podophyllotoxin | — | 14 |
| 19 | Trifluridine | — | 295 |
| 20 | Tripterygium | — | 300 |
| 21 | Budesonide | — | 1,000 |
| 22 | egcg | — | 300 |
| 23 | Flurandrenolone | — | 65 |
| 24 | Hexachlorophene | — | 300 |
| 25 | pictilisib | — | 25 |
| 26 | Niclosamide | — | 299 |
| 27 | Fingolimod Hydrochloride | — | 56 |
| 28 | Celecoxib | — | 295 |
About the Interleukin-20 family signaling Pathway
The Interleukin-20 family signaling pathway is catalogued in Reactome (ID: R-HSA-8854691) and involves 6 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK2, JAK3, STAT1, STAT3, STAT5A.