What compounds affect the RAC2 GTPase cycle pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the RAC2 GTPase cycle pathway (Reactome ID: R-HSA-9013404). These compounds target 14 genes within this pathway.

What genes are in the RAC2 GTPase cycle pathway?

The RAC2 GTPase cycle pathway involves 14 genes. Key genes include: ARHGAP35, BCR, CDC42, CYBB, EPHA2, NCF1, PAK4, PIK3R1, PIK3R2, PIK3R3.

RAC2 GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901340414 genes35 compounds

The RAC2 GTPase cycle pathway (Reactome ID: R-HSA-9013404) involves 14 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 BCR CDC42 CYBB EPHA2 NCF1 PAK4 PIK3R1 PIK3R2 PIK3R3 PLD2 RAB7A RACGAP1 TAOK3

Compounds Affecting RAC2 GTPase cycle

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	Sirolimus	—	300
4	Axitinib	—	298
5	pictilisib	—	25
6	ly294002	—	11
7	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
8	triolimus [Supplementary Concept]	—	33
9	pterostilbene	—	299
10	Imatinib Mesylate	—	300
11	Wortmannin	—	300
12	alpelisib	—	227
13	torin 1	—	10
14	Quercetin	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	chrysin	—	300
18	celastrol	—	300
19	Naloxone	—	299
20	Pueraria	—	300
21	Kaempferols	—	300
22	Catechin	—	300
23	Equilin	—	216
24	Methylene Blue	—	200
25	indirubin	—	300
26	Loxapine	—	30
27	alsterpaullone	—	12
28	kenpaullone	—	8
29	Dasatinib	—	299
30	Hydrocortisone	—	299
31	Hydrocortisone	—	298
32	Guanosine Diphosphate	—	300
33	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
34	Oleic Acid	—	112
35	casin	—	10

About the RAC2 GTPase cycle Pathway

The RAC2 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013404) and involves 14 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, BCR, CDC42, CYBB, EPHA2.