What compounds affect the RHOH GTPase cycle pathway?

31 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOH GTPase cycle pathway (Reactome ID: R-HSA-9013407). These compounds target 11 genes within this pathway.

What genes are in the RHOH GTPase cycle pathway?

The RHOH GTPase cycle pathway involves 11 genes. Key genes include: BUB1B-PAK6, CSK, LCK, PAK4, PAK5, PAK6, RAB7A, ROCK2, TUBA1B, VCP.

RHOH GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901340711 genes31 compounds

The RHOH GTPase cycle pathway (Reactome ID: R-HSA-9013407) involves 11 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BUB1B-PAK6 CSK LCK PAK4 PAK5 PAK6 RAB7A ROCK2 TUBA1B VCP ZAP70

Compounds Affecting RHOH GTPase cycle

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	Crizotinib	—	298
3	Axitinib	—	298
4	alsterpaullone	—	12
5	Sorafenib	—	300
6	Dasatinib	—	299
7	sp600125	—	117
8	Swainsonine	—	300
9	Edaravone	—	298
10	Acetic Acid Product of	—	300
11	Afatinib	—	297
12	piceatannol	—	300
13	tyrphostin ag 1478	—	4
14	Colchicine	—	300
15	Nocodazole Nocodazole is	—	215
16	Podophyllotoxin	—	14
17	Vincristine	—	299
18	Demecolcine	—	246
19	Maytansine	—	300
20	Noscapine	—	300
21	vinblastine sulfate	—	81
22	Vorinostat	—	299
23	hydroxyfasudil [Supplementary Concept]	—	11
24	Kinetin	—	300
25	Hexachlorophene	—	300
26	Oxytetracycline	—	300
27	egcg	—	300
28	Clotrimazole	—	296
29	Demeclocycline	—	5
30	Guanosine Diphosphate	—	300
31	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300

About the RHOH GTPase cycle Pathway

The RHOH GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013407) and involves 11 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BUB1B-PAK6, CSK, LCK, PAK4, PAK5.