What compounds affect the RAC3 GTPase cycle pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the RAC3 GTPase cycle pathway (Reactome ID: R-HSA-9013423). These compounds target 14 genes within this pathway.

What genes are in the RAC3 GTPase cycle pathway?

The RAC3 GTPase cycle pathway involves 14 genes. Key genes include: ABL2, ARHGAP35, BCR, CDC42, CYBB, EPHA2, NCF1, NOX1, PAK4, PIK3R1.

RAC3 GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901342314 genes35 compounds

The RAC3 GTPase cycle pathway (Reactome ID: R-HSA-9013423) involves 14 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL2 ARHGAP35 BCR CDC42 CYBB EPHA2 NCF1 NOX1 PAK4 PIK3R1 PIK3R2 RAB7A RACGAP1 TAOK3

Compounds Affecting RAC3 GTPase cycle

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	Axitinib	—	298
4	pictilisib	—	25
5	ly294002	—	11
6	Sirolimus	—	300
7	celastrol	—	300
8	Dasatinib	—	299
9	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
10	triolimus [Supplementary Concept]	—	33
11	pterostilbene	—	299
12	Imatinib Mesylate	—	300
13	Wortmannin	—	300
14	alpelisib	—	227
15	torin 1	—	10
16	Quercetin	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	chrysin	—	300
20	Naloxone	—	299
21	tyrphostin ag 1478	—	4
22	Pueraria	—	300
23	Kaempferols	—	300
24	Catechin	—	300
25	Equilin	—	216
26	Methylene Blue	—	200
27	indirubin	—	300
28	Loxapine	—	30
29	alsterpaullone	—	12
30	kenpaullone	—	8
31	Hydrocortisone	—	299
32	Hydrocortisone	—	298
33	Guanosine Diphosphate	—	300
34	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
35	casin	—	10

About the RAC3 GTPase cycle Pathway

The RAC3 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013423) and involves 14 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, ARHGAP35, BCR, CDC42, CYBB.