What compounds affect the Biosynthesis of D-series resolvins pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of D-series resolvins pathway (Reactome ID: R-HSA-9018676). These compounds target 4 genes within this pathway.

What genes are in the Biosynthesis of D-series resolvins pathway?

The Biosynthesis of D-series resolvins pathway involves 4 genes. Key genes include: ALOX5, GPX4, HPGD, LTA4H.

Biosynthesis of D-series resolvins

REACTOME PATHWAY

Reactome: R-HSA-90186764 genes58 compounds

The Biosynthesis of D-series resolvins pathway (Reactome ID: R-HSA-9018676) involves 4 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX5 GPX4 HPGD LTA4H

Compounds Affecting Biosynthesis of D-series resolvins

#	Compound	Targets Hit	Studies
1	Masoprocol	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Quercetin	—	300
4	Kaempferols	—	300
5	Hexachlorophene	—	300
6	Indomethacin	—	297
7	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
8	Disulfiram	—	297
9	Genistein	—	300
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Carmine Coloring matter from	—	300
12	Sulfinpyrazone	—	300
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Carbidopa	—	298
15	pd98059	—	7
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	Arachidonic Acid	—	245
18	plumbagin [Supplementary Concept]	—	300
19	salvin [Supplementary Concept]	—	300
20	DEET	—	298
21	diallyl trisulfide	—	246
22	Ethidium	—	300
23	hydroxyindoleacetic acid	—	300
24	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
25	Linoleic Acid	—	300
26	Niflumic Acid	—	300
27	amlexanox	—	96
28	cbd	—	298
29	obeticholic acid [Supplementary Concept]	—	271
30	Mepentol [Supplementary Concept]	—	184
31	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
32	Vitamin	—	295
33	Camptothecin	—	300
34	candesartan cilexetil [Supplementary Concept]	—	300
35	cannabidiol	—	296
36	Cefotetan	—	299
37	Cephaloglycin	—	102
38	Cisplatin	—	300
39	Dipyrone	—	298
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
41	Ethoxyquin Antioxidant; also	—	180
42	gamma-Linolenic Acid	—	300
43	Gestrinone	—	221
44	Lypressin	—	24
45	Methyldopa	—	297
46	Ornipressin	—	82
47	stx64	—	2
48	Trenbolone Acetate	—	300
49	Triiodothyronine	—	300
50	pterostilbene	—	299

About the Biosynthesis of D-series resolvins Pathway

The Biosynthesis of D-series resolvins pathway is catalogued in Reactome (ID: R-HSA-9018676) and involves 4 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5, GPX4, HPGD, LTA4H.