What compounds affect the Biosynthesis of protectins pathway?

248 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of protectins pathway (Reactome ID: R-HSA-9018681). These compounds target 4 genes within this pathway.

What genes are in the Biosynthesis of protectins pathway?

The Biosynthesis of protectins pathway involves 4 genes. Key genes include: ALOX15, CYP1A1, CYP1A2, LTA4H.

Biosynthesis of protectins

REACTOME PATHWAY

Reactome: R-HSA-90186814 genes248 compounds

The Biosynthesis of protectins pathway (Reactome ID: R-HSA-9018681) involves 4 genes and is affected by 248 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 CYP1A1 CYP1A2 LTA4H

Compounds Affecting Biosynthesis of protectins

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Quercetin	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	chrysin	—	300
6	Kaempferols	—	300
7	Ethoxyquin Antioxidant; also	—	180
8	Ethidium	—	300
9	Hesperidin	—	300
10	Iodoacetamide	—	300
11	cbd	—	298
12	fisetin	—	78
13	plumbagin [Supplementary Concept]	—	300
14	Aurintricarboxylic Acid	—	184
15	cannabidiol	—	296
16	ethopropazine hydrochloride	—	2
17	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
18	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
19	Procarbazine	—	299
20	Pseudoephedrine	—	298
21	tamarixetin	—	26
22	Phenacetin	—	300
23	Melatonin	—	297
24	Disulfiram	—	297
25	Flutamide	—	298
26	Genistein	—	300
27	Clotrimazole	—	296
28	Methoxsalen	—	300
29	Piribedil	—	300
30	Riluzole	—	298
31	Sulindac	—	297
32	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
33	Pueraria	—	300
34	Isoniazid Antibacterial agent used primarily as	—	299
35	Leflunomide	—	297
36	Nocodazole Nocodazole is	—	215
37	Clofibrate	—	299
38	Diuron	—	300
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	—	300
41	Vitamin K 3	—	300
42	Miconazole	—	298
43	Niclosamide	—	299
44	Perphenazine	—	297
45	Quipazine	—	300
46	Tolazamide	—	169
47	Fenofibrate	—	297
48	tyrphostin ag 1478	—	4
49	Methylene Blue	—	200
50	propyl gallate	—	261

About the Biosynthesis of protectins Pathway

The Biosynthesis of protectins pathway is catalogued in Reactome (ID: R-HSA-9018681) and involves 4 genes. In the BiohacksAI corpus, 248 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, CYP1A1, CYP1A2, LTA4H.