What compounds affect the Biosynthesis of E-series 18(S)-resolvins pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of E-series 18(S)-resolvins pathway (Reactome ID: R-HSA-9018896). These compounds target 5 genes within this pathway.

What genes are in the Biosynthesis of E-series 18(S)-resolvins pathway?

The Biosynthesis of E-series 18(S)-resolvins pathway involves 5 genes. Key genes include: ALOX15, ALOX5, GPX4, HPGD, LTA4H.

Biosynthesis of E-series 18(S)-resolvins

REACTOME PATHWAY

Reactome: R-HSA-90188965 genes71 compounds

The Biosynthesis of E-series 18(S)-resolvins pathway (Reactome ID: R-HSA-9018896) involves 5 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX5 GPX4 HPGD LTA4H

Compounds Affecting Biosynthesis of E-series 18(S)-resolvins

#	Compound	Targets Hit	Studies
1	Masoprocol	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Quercetin	—	300
4	Hexachlorophene	—	300
5	Arachidonic Acid	—	245
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Dipyrone	—	298
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Celecoxib	—	295
10	Ethidium	—	300
11	Ethoxyquin Antioxidant; also	—	180
12	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
13	Linoleic Acid	—	300
14	Kaempferols	—	300
15	Indomethacin	—	297
16	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
17	fisetin	—	78
18	Aurintricarboxylic Acid	—	184
19	Catechin	—	51
20	alpha-Linolenic Acid	—	300
21	brl 50481	—	5
22	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
23	Dactinomycin	—	297
24	dihydroxyflavone	—	256
25	Dihydroxyphenylalanine	—	300
26	ethopropazine hydrochloride	—	2
27	Iodoacetamide	—	300
28	Procarbazine	—	299
29	Pseudoephedrine	—	298
30	Disulfiram	—	297
31	Genistein	—	300
32	Carmine Coloring matter from	—	300
33	Sulfinpyrazone	—	300
34	Carbidopa	—	298
35	pd98059	—	7
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
37	plumbagin [Supplementary Concept]	—	300
38	salvin [Supplementary Concept]	—	300
39	DEET	—	298
40	diallyl trisulfide	—	246
41	hydroxyindoleacetic acid	—	300
42	Niflumic Acid	—	300
43	amlexanox	—	96
44	cbd	—	298
45	obeticholic acid [Supplementary Concept]	—	271
46	Mepentol [Supplementary Concept]	—	184
47	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
48	Vitamin	—	295
49	Camptothecin	—	300
50	candesartan cilexetil [Supplementary Concept]	—	300

About the Biosynthesis of E-series 18(S)-resolvins Pathway

The Biosynthesis of E-series 18(S)-resolvins pathway is catalogued in Reactome (ID: R-HSA-9018896) and involves 5 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX5, GPX4, HPGD, LTA4H.