What compounds affect the Interleukin-23 signaling pathway?

25 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-23 signaling pathway (Reactome ID: R-HSA-9020933). These compounds target 4 genes within this pathway.

What genes are in the Interleukin-23 signaling pathway?

The Interleukin-23 signaling pathway involves 4 genes. Key genes include: JAK2, P4HB, STAT3, TYK2.

Interleukin-23 signaling

REACTOME PATHWAY

Reactome: R-HSA-90209334 genes25 compounds

The Interleukin-23 signaling pathway (Reactome ID: R-HSA-9020933) involves 4 genes and is affected by 25 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

JAK2 P4HB STAT3 TYK2

Compounds Affecting Interleukin-23 signaling

#	Compound	Targets Hit	Studies
1	Azauridine	—	300
2	Cladribine	—	297
3	Dasatinib	—	299
4	Methylene Blue	—	200
5	2-Methoxyestradiol	—	300
6	Astemizole Antihistamine drug now withdrawn from	—	280
7	Azathioprine	—	300
8	Calcitriol	—	300
9	Camptothecin	—	300
10	Cytarabine	—	297
11	dihydrorotenone	—	13
12	Podophyllotoxin	—	14
13	streptonigrin	—	299
14	Trifluridine	—	295
15	Tripterygium	—	300
16	Crizotinib	—	298
17	Methotrexate	—	289
18	Axitinib	—	298
19	pictilisib	—	25
20	sp600125	—	117
21	Niclosamide	—	299
22	Fingolimod Hydrochloride	—	56
23	Celecoxib	—	295
24	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
25	Equilin	—	216

About the Interleukin-23 signaling Pathway

The Interleukin-23 signaling pathway is catalogued in Reactome (ID: R-HSA-9020933) and involves 4 genes. In the BiohacksAI corpus, 25 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK2, P4HB, STAT3, TYK2.