What compounds affect the Interleukin-27 signaling pathway?

27 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-27 signaling pathway (Reactome ID: R-HSA-9020956). These compounds target 4 genes within this pathway.

What genes are in the Interleukin-27 signaling pathway?

The Interleukin-27 signaling pathway involves 4 genes. Key genes include: JAK2, STAT1, STAT3, TYK2.

Interleukin-27 signaling

REACTOME PATHWAY

Reactome: R-HSA-90209564 genes27 compounds

The Interleukin-27 signaling pathway (Reactome ID: R-HSA-9020956) involves 4 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

JAK2 STAT1 STAT3 TYK2

Compounds Affecting Interleukin-27 signaling

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	streptonigrin	—	299
3	Azauridine	—	300
4	Cladribine	—	297
5	Dasatinib	—	299
6	2-Methoxyestradiol	—	300
7	Astemizole Antihistamine drug now withdrawn from	—	280
8	Azathioprine	—	300
9	Calcitriol	—	300
10	Camptothecin	—	300
11	Cytarabine	—	297
12	dihydrorotenone	—	13
13	Podophyllotoxin	—	14
14	Trifluridine	—	295
15	Tripterygium	—	300
16	Budesonide	—	1,000
17	egcg	—	300
18	Flurandrenolone	—	65
19	Hexachlorophene	—	300
20	Crizotinib	—	298
21	Methotrexate	—	289
22	Axitinib	—	298
23	pictilisib	—	25
24	sp600125	—	117
25	Niclosamide	—	299
26	Fingolimod Hydrochloride	—	56
27	Celecoxib	—	295

About the Interleukin-27 signaling Pathway

The Interleukin-27 signaling pathway is catalogued in Reactome (ID: R-HSA-9020956) and involves 4 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK2, STAT1, STAT3, TYK2.