What compounds affect the Iron uptake and transport pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the Iron uptake and transport pathway (Reactome ID: R-HSA-917937). These compounds target 5 genes within this pathway.

What genes are in the Iron uptake and transport pathway?

The Iron uptake and transport pathway involves 5 genes. Key genes include: ABCG2, ATP6V1B2, CUL1, NEDD8, SLC46A1.

Iron uptake and transport

REACTOME PATHWAY

Reactome: R-HSA-9179375 genes28 compounds

The Iron uptake and transport pathway (Reactome ID: R-HSA-917937) involves 5 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ATP6V1B2 CUL1 NEDD8 SLC46A1

Compounds Affecting Iron uptake and transport

#	Compound	Targets Hit	Studies
1	candesartan cilexetil [Supplementary Concept]	—	300
2	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
3	licochalcone	—	267
4	Quercetin	—	300
5	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	chrysin	—	300
8	Genistein	—	300
9	Kaempferols	—	300
10	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
11	Atorvastatin	—	1,000
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Sirolimus	—	300
14	Avapritinib	—	246
15	Caspofungin	—	299
16	Daunorubicin	—	298
17	Delavirdine	—	296
18	Estrone	—	300
19	Febuxostat	—	297
20	Fenofibrate	—	297
21	Furosemide	—	298
22	Sorafenib	—	300
23	Topotecan	—	300
24	Pemetrexed	—	299
25	Methotrexate	—	289
26	Leucovorin	—	297
27	ninhydrin	—	300
28	Enoxacin	—	299

About the Iron uptake and transport Pathway

The Iron uptake and transport pathway is catalogued in Reactome (ID: R-HSA-917937) and involves 5 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ATP6V1B2, CUL1, NEDD8, SLC46A1.