What compounds affect the Signaling by FLT3 ITD and TKD mutants pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FLT3 ITD and TKD mutants pathway (Reactome ID: R-HSA-9703648). These compounds target 7 genes within this pathway.

What genes are in the Signaling by FLT3 ITD and TKD mutants pathway?

The Signaling by FLT3 ITD and TKD mutants pathway involves 7 genes. Key genes include: BCL2L1, FLT3, GRB2, NOX4, PIK3R1, PIM1, STAT5A.

Signaling by FLT3 ITD and TKD mutants

REACTOME PATHWAY

Reactome: R-HSA-97036487 genes36 compounds

The Signaling by FLT3 ITD and TKD mutants pathway (Reactome ID: R-HSA-9703648) involves 7 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L1 FLT3 GRB2 NOX4 PIK3R1 PIM1 STAT5A

Compounds Affecting Signaling by FLT3 ITD and TKD mutants

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Kaempferols	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Sorafenib	—	300
6	pictilisib	—	25
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	kenpaullone	—	8
9	sp600125	—	117
10	ly294002	—	11
11	Axitinib	—	298
12	Crizotinib	—	298
13	Afatinib	—	297
14	tyrphostin ag 1295	—	1
15	tyrphostin ag 1478	—	4
16	fisetin	—	78
17	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
18	alsterpaullone	—	12
19	Colchicine	—	300
20	piceatannol	—	300
21	paxilline	—	42
22	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
23	Anthralin	—	299
24	Aurintricarboxylic Acid	—	184
25	Domperidone	—	299
26	Metergoline	—	144
27	Masoprocol	—	300
28	Oxytetracycline	—	300
29	Tetracycline	—	300
30	vinblastine sulfate	—	81
31	Wortmannin	—	300
32	alpelisib	—	227
33	Sirolimus	—	300
34	torin 1	—	10
35	celastrol	—	300
36	Dactinomycin	—	297

About the Signaling by FLT3 ITD and TKD mutants Pathway

The Signaling by FLT3 ITD and TKD mutants pathway is catalogued in Reactome (ID: R-HSA-9703648) and involves 7 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L1, FLT3, GRB2, NOX4, PIK3R1.