What compounds affect the Heme signaling pathway?

287 compounds in the BiohacksAI corpus have documented interactions with genes in the Heme signaling pathway (Reactome ID: R-HSA-9707616). These compounds target 18 genes within this pathway.

What genes are in the Heme signaling pathway?

The Heme signaling pathway involves 18 genes. Key genes include: CARM1, CREB1, CREBBP, EP300, HBA1, HBA2, HBB, HDAC3, NCOA1, NCOR1.

Heme signaling

REACTOME PATHWAY

Reactome: R-HSA-970761618 genes287 compounds

The Heme signaling pathway (Reactome ID: R-HSA-9707616) involves 18 genes and is affected by 287 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREB1 CREBBP EP300 HBA1 HBA2 HBB HDAC3 NCOA1 NCOR1 NFE2L2 NR1D1 PPARA RORA RXRA SIRT1 SLC46A1 XPO1

Compounds Affecting Heme signaling

#	Compound	Targets Hit	Studies
1	Azacitidine	—	298
2	Azacitidine	—	300
3	Genistein	—	300
4	Quercetin	—	300
5	Bortezomib	—	300
6	Ethidium	—	300
7	Nocodazole Nocodazole is	—	215
8	Methotrexate	—	289
9	Dactinomycin	—	297
10	Daunorubicin	—	298
11	Vorinostat	—	299
12	Progesterone	—	299
13	Testosterone	—	299
14	Aldosterone	—	300
15	Gemfibrozil	—	297
16	diallyl trisulfide	—	246
17	Resveratrol	—	298
18	Colchicine	—	300
19	Vitamin	—	295
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	alpha-Linolenic Acid	—	300
22	Rotenone	—	300
23	Methylene Blue	—	200
24	Nitrofurazone	—	300
25	Azathioprine	—	300
26	Niclosamide	—	299
27	vinblastine sulfate	—	81
28	chrysin	—	300
29	Digoxin	—	299
30	Flutamide	—	298
31	Linoleic Acid	—	300
32	Vitamin K 3	—	300
33	Podophyllotoxin	—	14
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
35	Oxyphenbutazone	—	300
36	Celecoxib	—	295
37	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
38	Nisoldipine	—	297
39	Retinaldehyde	—	300
40	Troglitazone	—	299
41	Dihydrotestosterone	—	300
42	Fenofibrate	—	297
43	Niflumic Acid	—	300
44	o-Phthalaldehyde	—	300
45	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
46	Tilorone	—	300
47	Corticosterone	—	300
48	dimethyl formamide	—	260
49	Dimethylformamide	—	300
50	Disulfiram	—	297

About the Heme signaling Pathway

The Heme signaling pathway is catalogued in Reactome (ID: R-HSA-9707616) and involves 18 genes. In the BiohacksAI corpus, 287 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREB1, CREBBP, EP300, HBA1.