What compounds target NFE2L2?

BiohacksAI has identified 202 compounds that interact with NFE2L2 (NFE2 like bZIP transcription factor 2). Top compounds include: Resveratrol, Colchicine, Vitamin, Azacitidine, Azacitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NFE2L2 (NFE2 like bZIP)?

NFE2L2 is NFE2 like bZIP transcription factor 2. It is a molecular target for 202 compounds documented in PubMed bioassay data. UniProt ID: Q16236. NCBI Gene ID: 4780.

NFE2L2

MOLECULAR TARGET

NFE2 like bZIP transcription factor 2

UniProt: Q16236 NCBI Gene: 4780202 compounds

NFE2L2 (NFE2 like bZIP transcription factor 2) is targeted by 202 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NFE2L2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Resveratrol	2.77	15
2	Colchicine	2.64	13
3	Vitamin	2.56	12
4	Azacitidine	2.56	12
5	Azacitidine	2.56	12
6	Genistein	2.40	10
7	Apigenin 5,7,4'-trihydroxy-flavone,	2.30	9
8	alpha-Linolenic Acid	2.30	9
9	Oxymetholone	2.30	9
10	Rotenone	2.30	9
11	Methylene Blue	2.20	8
12	Ethoxyquin Antioxidant; also	2.20	8
13	Nitrofurazone	2.20	8
14	Quercetin	2.08	7
15	Azathioprine	2.08	7
16	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	2.08	7
17	Mestranol	2.08	7
18	methoprene	2.08	7
19	Niclosamide	2.08	7
20	Phenelzine	2.08	7
21	vinblastine sulfate	2.08	7
22	chrysin	1.95	6
23	alyssin [Supplementary Concept]	1.95	6
24	Digitoxin	1.95	6
25	Digoxin	1.95	6
26	Flutamide	1.95	6
27	Hexachlorophene	1.95	6
28	Linoleic Acid	1.95	6
29	Vitamin K 3	1.95	6
30	Nitrofurantoin	1.95	6
31	Ouabain	1.95	6
32	Podophyllotoxin	1.95	6
33	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.95	6
34	Toxaphene	1.95	6
35	DEAD-box RNA Helicases	1.79	5
36	Thioctic Acid	1.79	5
37	amlexanox	1.79	5
38	Bortezomib	1.79	5
39	Chlormadinone Acetate	1.79	5
40	Ethidium	1.79	5
41	Feprazone	1.79	5
42	Idazoxan	1.79	5
43	Leflunomide	1.79	5
44	Nocodazole Nocodazole is	1.79	5
45	Oxyphenbutazone	1.79	5
46	Thioctic Acid	1.79	5
47	Caffeine	1.61	4
48	propyl gallate	1.61	4
49	Ascorbic Acid	1.61	4
50	Methotrexate	1.61	4

Showing top 50 of 202 compounds. Use the BiohacksAI search to explore all NFE2L2 modulators.

About NFE2L2 as a Drug Target

NFE2L2 (NFE2 like bZIP transcription factor 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 202 compounds with documented NFE2L2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NFE2L2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.