SARS-CoV-1 targets host intracellular signalling and regulatory pathways

Q: What compounds affect the SARS-CoV-1 targets host intracellular signalling and regulatory pathways pathway?

67 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-1 targets host intracellular signalling and regulatory pathways pathway (Reactome ID: R-HSA-9735871). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97358716 genes67 compounds

The SARS-CoV-1 targets host intracellular signalling and regulatory pathways pathway (Reactome ID: R-HSA-9735871) involves 6 genes and is affected by 67 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EP300 PDPK1 PSMC6 SMAD3 YWHAB YWHAG

Compounds Affecting SARS-CoV-1 targets host intracellular signalling and regulatory pathways

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	Quercetin	—	300
4	egcg	—	300
5	Bortezomib	—	300
6	Masoprocol	—	300
7	Calcimycin	—	216
8	cycloheximide	—	300
9	Anisomycin	—	247
10	Azacitidine	—	298
11	Azacitidine	—	300
12	Disulfiram	—	297
13	Nisoldipine	—	297
14	Tubercidin	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Kaempferols	—	300
17	cardamonin	—	180
18	Colchicine	—	300
19	Dactinomycin	—	297
20	Danazol	—	298
21	Dasatinib	—	299
22	Dinitrochlorobenzene	—	300
23	Ethidium	—	300
24	Flutamide	—	298
25	Loratadine	—	296
26	Oxyphenbutazone	—	300
27	Podophyllotoxin	—	14
28	vinblastine sulfate	—	81
29	Vincristine	—	299
30	chrysin	—	300
31	Fluoxetine	—	1,000
32	Methylene Blue	—	200
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Celecoxib	—	295
36	Ciclopirox	—	88
37	Cladribine	—	297
38	Daunorubicin	—	298
39	Digitoxin	—	300
40	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
41	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
42	Domperidone	—	299
43	Emetine	—	298
44	Equilin	—	216
45	Ethinyl Estradiol	—	300
46	Ezetimibe	—	296
47	Fluspirilene	—	74
48	Hexachlorophene	—	300
49	Idazoxan	—	300
50	Lynestrenol	—	299

About the SARS-CoV-1 targets host intracellular signalling and regulatory pathways Pathway

The SARS-CoV-1 targets host intracellular signalling and regulatory pathways pathway is catalogued in Reactome (ID: R-HSA-9735871) and involves 6 genes. In the BiohacksAI corpus, 67 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EP300, PDPK1, PSMC6, SMAD3, YWHAB.