What compounds affect the Gastrulation pathway?

140 compounds in the BiohacksAI corpus have documented interactions with genes in the Gastrulation pathway (Reactome ID: R-HSA-9758941). These compounds target 44 genes within this pathway.

What genes are in the Gastrulation pathway?

The Gastrulation pathway involves 44 genes. Key genes include: ADRM1, CREBBP, EP300, EPHA4, FGFR1, KAT2A, KAT2B, PAX8, PSMA1, PSMA2.

Gastrulation

REACTOME PATHWAY

Reactome: R-HSA-975894144 genes140 compounds

The Gastrulation pathway (Reactome ID: R-HSA-9758941) involves 44 genes and is affected by 140 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CREBBP EP300 EPHA4 FGFR1 KAT2A KAT2B PAX8 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+14 more

Compounds Affecting Gastrulation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Colchicine	—	300
4	egcg	—	300
5	Nocodazole Nocodazole is	—	215
6	Dasatinib	—	299
7	Podophyllotoxin	—	14
8	cycloheximide	—	300
9	Anisomycin	—	247
10	Azacitidine	—	298
11	Azacitidine	—	300
12	Disulfiram	—	297
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Quercetin	—	300
15	Dactinomycin	—	297
16	Ethidium	—	300
17	vinblastine sulfate	—	81
18	chrysin	—	300
19	Astemizole Antihistamine drug now withdrawn from	—	280
20	Ciclopirox	—	88
21	Daunorubicin	—	298
22	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
23	Emetine	—	298
24	Hexachlorophene	—	300
25	Rotenone	—	300
26	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
27	Calcimycin	—	216
28	alsterpaullone	—	12
29	Nisoldipine	—	297
30	Tubercidin	—	300
31	Kaempferols	—	300
32	Danazol	—	298
33	Dinitrochlorobenzene	—	300
34	Flutamide	—	298
35	Loratadine	—	296
36	Oxyphenbutazone	—	300
37	Vincristine	—	299
38	Fluoxetine	—	1,000
39	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
40	Celecoxib	—	295
41	Cladribine	—	297
42	Domperidone	—	299
43	Equilin	—	216
44	Ethinyl Estradiol	—	300
45	Ezetimibe	—	296
46	Idazoxan	—	300
47	Lynestrenol	—	299
48	Masoprocol	—	300
49	o-Phthalaldehyde	—	300
50	Perphenazine	—	297

About the Gastrulation Pathway

The Gastrulation pathway is catalogued in Reactome (ID: R-HSA-9758941) and involves 44 genes. In the BiohacksAI corpus, 140 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CREBBP, EP300, EPHA4, FGFR1.