What compounds affect the Formation of paraxial mesoderm pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Formation of paraxial mesoderm pathway (Reactome ID: R-HSA-9793380). These compounds target 38 genes within this pathway.

What genes are in the Formation of paraxial mesoderm pathway?

The Formation of paraxial mesoderm pathway involves 38 genes. Key genes include: ADRM1, CREBBP, EP300, EPHA4, FGFR1, KAT2A, KAT2B, PSMA1, PSMA2, PSMA3.

Formation of paraxial mesoderm

REACTOME PATHWAY

Reactome: R-HSA-979338038 genes47 compounds

The Formation of paraxial mesoderm pathway (Reactome ID: R-HSA-9793380) involves 38 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CREBBP EP300 EPHA4 FGFR1 KAT2A KAT2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+8 more

Compounds Affecting Formation of paraxial mesoderm

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	egcg	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Sorafenib	—	300
6	Dasatinib	—	299
7	plumbagin [Supplementary Concept]	—	300
8	Aurintricarboxylic Acid	—	184
9	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
10	DEAD-box RNA Helicases	—	169
11	Thioctic Acid	—	298
12	Arachidonic Acid	—	245
13	Oleic Acid	—	112
14	alpha-Linolenic Acid	—	300
15	candesartan cilexetil [Supplementary Concept]	—	300
16	Cisplatin	—	300
17	diallyl trisulfide	—	246
18	Estramustine	—	300
19	gamma-Linolenic Acid	—	300
20	Hexachlorophene	—	300
21	Iodoacetamide	—	300
22	Lithocholic Acid	—	300
23	Oxytetracycline	—	300
24	rafoxanide	—	172
25	Ritonavir	—	298
26	Thioctic Acid	—	300
27	Trazodone	—	297
28	Disulfiram	—	297
29	4-Hydroxybenzoate-3-Monooxygenase	—	300
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	chrysin	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Quercetin	—	300
34	Genistein	—	300
35	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
36	Axitinib	—	298
37	alsterpaullone	—	12
38	sp600125	—	117
39	Papaverine	—	299
40	Colchicine	—	300
41	Etazolate	—	66
42	Nocodazole Nocodazole is	—	215
43	11-hydroxypalmatine [Supplementary Concept]	—	238
44	np1	—	81
45	Crizotinib	—	298
46	Pioglitazone	—	297
47	Harmaline	—	300

About the Formation of paraxial mesoderm Pathway

The Formation of paraxial mesoderm pathway is catalogued in Reactome (ID: R-HSA-9793380) and involves 38 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CREBBP, EP300, EPHA4, FGFR1.