What compounds affect the Ciprofloxacin ADME pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Ciprofloxacin ADME pathway (Reactome ID: R-HSA-9793528). These compounds target 5 genes within this pathway.

What genes are in the Ciprofloxacin ADME pathway?

The Ciprofloxacin ADME pathway involves 5 genes. Key genes include: ABCG2, ALB, SLC22A1, SLC22A8, SLCO1A2.

Ciprofloxacin ADME

REACTOME PATHWAY

Reactome: R-HSA-97935285 genes82 compounds

The Ciprofloxacin ADME pathway (Reactome ID: R-HSA-9793528) involves 5 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ALB SLC22A1 SLC22A8 SLCO1A2

Compounds Affecting Ciprofloxacin ADME

#	Compound	Targets Hit	Studies
1	Dinoprost	—	252
2	Dinoprostone	—	296
3	Probenecid	—	298
4	Dicloxacillin	—	297
5	Oxacillin	—	298
6	Penicillin G	—	298
7	cefadroxil	—	299
8	Thioctic Acid	—	182
9	Carnitine	—	300
10	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
11	Azlocillin	—	300
12	cefaclor	—	299
13	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
14	Cefazolin	—	300
15	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
16	cefotaxime	—	299
17	Cefoxitin	—	300
18	Ceftriaxone	—	299
19	Cephaloridine	—	300
20	Cloxacillin	—	299
21	Indomethacin	—	297
22	Methicillin	—	299
23	Nafcillin	—	297
24	Penicillin V	—	300
25	piperacillin	—	298
26	Tazobactam	—	298
27	licochalcone	—	267
28	Quercetin	—	300
29	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	chrysin	—	300
32	Genistein	—	300
33	Kaempferols	—	300
34	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
35	Atorvastatin	—	1,000
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	Sirolimus	—	300
38	Avapritinib	—	246
39	candesartan cilexetil [Supplementary Concept]	—	300
40	Caspofungin	—	299
41	Daunorubicin	—	298
42	Delavirdine	—	296
43	Estrone	—	300
44	Febuxostat	—	297
45	Fenofibrate	—	297
46	Furosemide	—	298
47	Sorafenib	—	300
48	Topotecan	—	300
49	Clonidine	—	299
50	Procainamide	—	297

About the Ciprofloxacin ADME Pathway

The Ciprofloxacin ADME pathway is catalogued in Reactome (ID: R-HSA-9793528) and involves 5 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ALB, SLC22A1, SLC22A8, SLCO1A2.