What genes are in the NFE2L2 regulating MDR associated enzymes pathway?

The NFE2L2 regulating MDR associated enzymes pathway involves 6 genes. Key genes include: ABCC1, ABCC3, ABCG2, CREBBP, EP300, NFE2L2.

NFE2L2 regulating MDR associated enzymes

Q: What compounds affect the NFE2L2 regulating MDR associated enzymes pathway?

238 compounds in the BiohacksAI corpus have documented interactions with genes in the NFE2L2 regulating MDR associated enzymes pathway (Reactome ID: R-HSA-9818032). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98180326 genes238 compounds

The NFE2L2 regulating MDR associated enzymes pathway (Reactome ID: R-HSA-9818032) involves 6 genes and is affected by 238 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 CREBBP EP300 NFE2L2

Compounds Affecting NFE2L2 regulating MDR associated enzymes

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Quercetin	—	300
3	Kaempferols	—	300
4	Daunorubicin	—	298
5	Delavirdine	—	296
6	Colchicine	—	300
7	Genistein	—	300
8	chrysin	—	300
9	Nocodazole Nocodazole is	—	215
10	Methotrexate	—	289
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Febuxostat	—	297
13	Fenofibrate	—	297
14	candesartan cilexetil [Supplementary Concept]	—	300
15	Papaverine	—	299
16	Triamcinolone	—	300
17	Rimonabant	—	300
18	Abacavir	—	295
19	Emtricitabine	—	292
20	Lamivudine	—	299
21	Resveratrol	—	298
22	Vitamin	—	295
23	Azacitidine	—	298
24	Azacitidine	—	300
25	alpha-Linolenic Acid	—	300
26	Oxymetholone	—	298
27	Rotenone	—	300
28	Methylene Blue	—	200
29	Ethoxyquin Antioxidant; also	—	180
30	Nitrofurazone	—	300
31	Azathioprine	—	300
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Mestranol	—	300
34	methoprene	—	300
35	Niclosamide	—	299
36	Phenelzine	—	2
37	vinblastine sulfate	—	81
38	alyssin [Supplementary Concept]	—	300
39	Digitoxin	—	300
40	Digoxin	—	299
41	Flutamide	—	298
42	Hexachlorophene	—	300
43	Linoleic Acid	—	300
44	Vitamin K 3	—	300
45	Nitrofurantoin	—	297
46	Ouabain	—	300
47	Podophyllotoxin	—	14
48	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
49	Toxaphene	—	299
50	DEAD-box RNA Helicases	—	169

About the NFE2L2 regulating MDR associated enzymes Pathway

The NFE2L2 regulating MDR associated enzymes pathway is catalogued in Reactome (ID: R-HSA-9818032) and involves 6 genes. In the BiohacksAI corpus, 238 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, CREBBP, EP300.