Respiratory syncytial virus (RSV) genome replication, transcription and translation

Q: What compounds affect the Respiratory syncytial virus (RSV) genome replication, transcription and translation pathway?

61 compounds in the BiohacksAI corpus have documented interactions with genes in the Respiratory syncytial virus (RSV) genome replication, transcription and translation pathway (Reactome ID: R-HSA-9820965). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-982096511 genes61 compounds

The Respiratory syncytial virus (RSV) genome replication, transcription and translation pathway (Reactome ID: R-HSA-9820965) involves 11 genes and is affected by 61 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK2A1 CSNK2A2 CSNK2B FURIN HSP90AA1 HSP90AB1 HSPA8 KPNB1 PPP1CA PPP1CC XPO1

Compounds Affecting Respiratory syncytial virus (RSV) genome replication, transcription and translation

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Quercetin	—	300
3	Tetracycline	—	300
4	Hexachlorophene	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	fisetin	—	78
8	Kaempferols	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	chrysin	—	300
11	Vanillic Acid	—	300
12	ly294002	—	11
13	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
14	triolimus [Supplementary Concept]	—	33
15	monorden	—	8
16	gedunin	—	54
17	celastrol	—	300
18	Novobiocin	—	300
19	caffeic acid	—	300
20	Masoprocol	—	300
21	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
22	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
23	ag490	—	14
24	Calcimycin	—	216
25	Clotrimazole	—	296
26	Idarubicin	—	299
27	piceatannol	—	300
28	Nitroprusside	—	299
29	Chlorhexidine	—	299
30	2-Chloroadenosine 2-Chloroadenosine.	—	300
31	Calcitriol	—	300
32	Ciclopirox	—	88
33	cycloheximide	—	300
34	deguelin [Supplementary Concept]	—	151
35	Disulfiram	—	297
36	Indazoles	—	300
37	Miconazole	—	298
38	specioside	—	6
39	Wortmannin	—	300
40	Dichlororibofuranosylbenzimidazole	—	26
41	alsterpaullone	—	12
42	kenpaullone	—	8
43	sp600125	—	117
44	Anthralin	—	299
45	Mometasone Furoate	—	292
46	Oxytetracycline	—	300
47	Thyroxine	—	994
48	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
49	Aurintricarboxylic Acid	—	184
50	Fluspirilene	—	74

About the Respiratory syncytial virus (RSV) genome replication, transcription and translation Pathway

The Respiratory syncytial virus (RSV) genome replication, transcription and translation pathway is catalogued in Reactome (ID: R-HSA-9820965) and involves 11 genes. In the BiohacksAI corpus, 61 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK2A1, CSNK2A2, CSNK2B, FURIN, HSP90AA1.