Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
REACTOME PATHWAYThe Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex pathway (Reactome ID: R-HSA-9843970) involves 4 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Disulfiram | — | 297 |
| 2 | s adenosylhomocysteine | — | 300 |
| 3 | Glutathione | — | 300 |
| 4 | Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in | — | 300 |
| 5 | Dimethyl Sulfoxide | — | 300 |
| 6 | ninhydrin | — | 300 |
| 7 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 8 | Aurintricarboxylic Acid | — | 184 |
| 9 | Cisplatin | — | 300 |
| 10 | Nitroprusside | — | 299 |
| 11 | Quercetin | — | 300 |
| 12 | Methotrexate | — | 289 |
| 13 | daph | — | 2 |
| 14 | Dequalinium | — | 46 |
| 15 | Diamide | — | 300 |
| 16 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 17 | Fluspirilene | — | 74 |
| 18 | Idarubicin | — | 299 |
| 19 | Iodoacetamide | — | 300 |
| 20 | Levodopa | — | 297 |
| 21 | Methyldopa | — | 297 |
| 22 | Nicardipine | — | 94 |
| 23 | Perphenazine | — | 297 |
| 24 | piceatannol | — | 300 |
| 25 | Promethazine | — | 121 |
| 26 | Reserpine | — | 297 |
| 27 | Thioridazine | — | 35 |
| 28 | trequinsin hydrochloride | — | 1 |
| 29 | tyrphostin 9 | — | 2 |
| 30 | Cyproheptadine | — | 299 |
| 31 | Gliotoxin | — | 300 |
About the Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Pathway
The Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex pathway is catalogued in Reactome (ID: R-HSA-9843970) and involves 4 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EHMT1, EHMT2, MPHOSPH8, SETDB1.