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Bicuculline

An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.

300+ PubMed studies analyzed · Evidence Score: 42.9

Research Domains

Bicuculline has been studied across 22 research domains including 🧘 Stress & Anxiety, 🧠 Memory, 🧠 Focus & Attention, 🧠 Learning, 🦴 Bone & Joint. The primary research focus is 🧘 Stress & Anxiety with 69% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Bicuculline, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Pregnanolone
17 shared targets
Etomidate
16 shared targets
Ciprofloxacin
15 shared targets
Etiocholanolone
16 shared targets
Picrotoxin
16 shared targets
Androsterone
16 shared targets
gamma-Aminobutyric
18 shared targets
Ondansetron
16 shared targets
Triiodothyronine
16 shared targets
flumazenil
6 shared targets
Loading evidence profile...

This evidence profile for Bicuculline is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.