BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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B
BiohacksAI/Targets/ROCK1
MOLECULAR TARGET

ROCK1

Rho associated coiled-coil containing protein kinase 1

46 compounds · BiohacksAI corpus v20260307-01

46
compounds
Compounds
46
Gene Symbol
ROCK1
NCBI Gene
6093

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About ROCK1

ROCK1 (Rho associated coiled-coil containing protein kinase 1) is a biological target studied in biomedical research. The BiohacksAI corpus identifies 46 compounds with documented interactions with this target, based on BindingDB assay data and PubMed literature.

Compounds Targeting ROCK1 (46)
1
Tofacitinib
4.65
confidence
2
Alvocidib
4.52
confidence
3
Ruxolitinib
4.23
confidence
4
Bosutinib
4.08
confidence
5
Midostaurin
3.85
confidence
6
Fasudil
3.66
confidence
7
Baricitinib
3.56
confidence
8
Y 27632
3.47
confidence
9
Tae 684
3.43
confidence
10
Fedratinib
3.40
confidence
11
Ha1077
11
studies
3.18
confidence
12
Dovitinib
3.09
confidence
13
Upadacitinib
3.09
confidence
14
Lestaurtinib
3.04
confidence
15
Momelotinib
2.89
confidence
16
R 406
2.83
confidence
17
Capivasertib
2.77
confidence
18
Kw 2449
2.64
confidence
19
Gsk 690693
2.64
confidence
20
Ast 487
2.56
confidence
21
Zotiraciclib
2.56
confidence
22
Gsk 461364
2.40
confidence
23
Ripasudil
2.40
confidence
24
Hydroxyfasudil
2.40
confidence
25
Belumosudil
2.30
confidence
26
Su 014813
2.20
confidence
27
Decernotinib
2.20
confidence
28
Y 39983
2.20
confidence
29
Rg 547
2.08
confidence
30
Gsk 269962a
2.08
confidence
31
Gsk 180736a
2.08
confidence
32
Uprosertib
1.95
confidence
33
Sel 120 Free Base
1.95
confidence
34
Lx 7101
1.95
confidence
35
Netarsudil
1.95
confidence
36
Ucn 01
1.79
confidence
37
Ilorasertib
1.79
confidence
38
Afuresertib
1.79
confidence
39
Sar 407899 Free Base
1.79
confidence
40
Alsterpaullone
12
studies
0.69
confidence
41
Crizotinib
298
studies
0.69
confidence
42
Harmine
300
studies
0.69
confidence
43
Kenpaullone
8
studies
0.69
confidence
44
Sp600125
117
studies
0.69
confidence
45
Bdb Chembl3401984
2
studies
0.69
confidence
46
Bdb Chembl3401987
2
studies
0.69
confidence
Top 46 compounds by confidence score. Derived from BindingDB assay data.
Data Source
Corpusv20260307-01
SourceBindingDB · ChEMBL · PubMed

All data is computationally derived from published research. Not medical advice. Independent validation required.