What compounds target ATAD5?

BiohacksAI has identified 71 compounds that interact with ATAD5 (ATPase family AAA domain containing 5). Top compounds include: Genistein, Resveratrol, Colchicine, Disulfiram, streptonigrin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ATAD5 (ATPase family AAA)?

ATAD5 is ATPase family AAA domain containing 5. It is a molecular target for 71 compounds documented in PubMed bioassay data. UniProt ID: Q96QE3. NCBI Gene ID: 79915.

ATAD5

MOLECULAR TARGET

ATPase family AAA domain containing 5

UniProt: Q96QE3 NCBI Gene: 7991571 compounds

ATAD5 (ATPase family AAA domain containing 5) is targeted by 71 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ATAD5

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Genistein	2.20	8
2	Resveratrol	2.20	8
3	Colchicine	2.08	7
4	Disulfiram	2.08	7
5	streptonigrin	2.08	7
6	Anisomycin	1.79	5
7	Azacitidine	1.79	5
8	Azacitidine	1.79	5
9	Leflunomide	1.79	5
10	tyrphostin ag 1478	1.79	5
11	Apigenin 5,7,4'-trihydroxy-flavone,	1.61	4
12	Bortezomib	1.61	4
13	Nocodazole Nocodazole is	1.61	4
14	vinblastine sulfate	1.61	4
15	Vorinostat	1.61	4
16	Pueraria	1.39	3
17	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	1.39	3
18	o-Phthalaldehyde	1.39	3
19	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.39	3
20	amlexanox	1.10	2
21	Axitinib	1.10	2
22	Calcimycin	1.10	2
23	Daunorubicin	1.10	2
24	Demecolcine	1.10	2
25	Digoxin	1.10	2
26	dilazep	1.10	2
27	Dinitrochlorobenzene	1.10	2
28	Febuxostat	1.10	2
29	Glutaral	1.10	2
30	Idarubicin	1.10	2
31	Ouabain	1.10	2
32	piceatannol	1.10	2
33	Podophyllotoxin	1.10	2
34	Reserpine	1.10	2
35	Riluzole	1.10	2
36	trichostatic acid [Supplementary Concept] related to trichostatin	1.10	2
37	tyrphostin ag 1295	1.10	2
38	Vincristine	1.10	2
39	Methylene Blue	0.69	1
40	Quercetin	0.69	1
41	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	0.69	1
42	2-Acetylaminofluorene	0.69	1
43	Azathioprine	0.69	1
44	calycosin	0.69	1
45	Camptothecin	0.69	1
46	Carboxin	0.69	1
47	Ciclopirox	0.69	1
48	cycloheximide	0.69	1
49	daph	0.69	1
50	Desonide	0.69	1

Showing top 50 of 71 compounds. Use the BiohacksAI search to explore all ATAD5 modulators.

About ATAD5 as a Drug Target

ATAD5 (ATPase family AAA domain containing 5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 71 compounds with documented ATAD5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ATAD5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.