What compounds target BCL2?

BiohacksAI has identified 48 compounds that interact with BCL2 (Apoptosis regulator Bcl-2). Top compounds include: epigalocatechin gallate, gossypol, nutlin 3, formononetin, abt 737. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is BCL2 (Apoptosis regulator Bcl-2)?

BCL2 is Apoptosis regulator Bcl-2. It is a molecular target for 48 compounds documented in PubMed bioassay data.

BCL2

MOLECULAR TARGET

Apoptosis regulator Bcl-2

48 compounds

BCL2 (Apoptosis regulator Bcl-2) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting BCL2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	epigalocatechin gallate	5.40	220
2	gossypol	4.42	82
3	nutlin 3	4.42	82
4	formononetin	4.06	57
5	abt 737	4.04	56
6	epicatechin gallate	3.95	51
7	gambogic acid	3.69	39
8	venetoclax	3.69	39
9	navitoclax	3.53	33
10	athraquinones a	3.14	22
11	gallocatechin gallate	3.09	21
12	azd 5991	2.20	8
13	obatoclax	2.08	7
14	tapotoclax	1.95	6
15	apogossypol	1.79	5
16	theaflavin	1.79	5
17	artemisia argyi	1.00	1
18	artemisia capillaris	1.00	1
19	aster tataricus	1.00	1
20	citrus reticulata	1.00	1
21	Curcuma	1.00	1
22	forsythia suspensa	1.00	1
23	ligusticum chuanxiong	1.00	1
24	lonicera japonica	1.00	1
25	pinellia ternata	1.00	1
26	Piper nigrum	1.00	1
27	schisandra chinensis	1.00	1
28	Syzygium	1.00	1
29	Zingiber officinale Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as	1.00	1
30	bdb chembl3793424	0.69	1
31	aconitum carmichaelii	0.50	1
32	aloe vera	0.50	1
33	artemisia annua	0.50	1
34	aucklandia lappa	0.50	1
35	chaenomeles speciosa	0.50	1
36	corydalis yanhusuo	0.50	1
37	dendrobium nobile	0.50	1
38	ephedra sinica	0.50	1
39	Foeniculum	0.50	1
40	glycyrrhiza uralensis	0.50	1
41	morus alba	0.50	1
42	mosla chinensis	0.50	1
43	Nelumbo	0.50	1
44	paeonia lactiflora	0.50	1
45	polygonum cuspidatum	0.50	1
46	sophora flavescens	0.50	1
47	verbena officinalis	0.50	1
48	ziziphus jujuba	0.50	1

About BCL2 as a Drug Target

BCL2 (Apoptosis regulator Bcl-2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented BCL2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

BCL2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.