HTR3A
MOLECULAR TARGET5-hydroxytryptamine receptor 3A
HTR3A (5-hydroxytryptamine receptor 3A) is targeted by 18 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HTR3A
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Ondansetron | 3.83 | 45 |
| 2 | Quipazine | 3.26 | 25 |
| 3 | Metoclopramide | 3.09 | 21 |
| 4 | Mianserin | 1.95 | 6 |
| 5 | Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent | 1.10 | 2 |
| 6 | Aripiprazole | 1.10 | 2 |
| 7 | Mescaline Hallucinogenic alkaloid isolated from | 1.10 | 2 |
| 8 | Octopamine | 1.10 | 2 |
| 9 | Pergolide | 1.10 | 2 |
| 10 | Sumatriptan | 1.10 | 2 |
| 11 | Amlodipine | 0.69 | 1 |
| 12 | Amoxapine | 0.69 | 1 |
| 13 | Astemizole Antihistamine drug now withdrawn from | 0.69 | 1 |
| 14 | Chlorhexidine | 0.69 | 1 |
| 15 | Cyproheptadine | 0.69 | 1 |
| 16 | Loxapine | 0.69 | 1 |
| 17 | Nortriptyline | 0.69 | 1 |
| 18 | Vortioxetine | 0.69 | 1 |
About HTR3A as a Drug Target
HTR3A (5-hydroxytryptamine receptor 3A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 18 compounds with documented HTR3A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HTR3A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.