What compounds target NR1I2?

BiohacksAI has identified 259 compounds that interact with NR1I2 (nuclear receptor subfamily 1 group I member 2). Top compounds include: Ethinyl Estradiol, oxatomide [Supplementary Concept] structure;, Clotrimazole, Fulvestrant, Nisoldipine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NR1I2 (nuclear receptor subfamily)?

NR1I2 is nuclear receptor subfamily 1 group I member 2. It is a molecular target for 259 compounds documented in PubMed bioassay data. UniProt ID: ADZ17384. NCBI Gene ID: 8856.

NR1I2

MOLECULAR TARGET

nuclear receptor subfamily 1 group I member 2

UniProt: ADZ17384 NCBI Gene: 8856259 compounds

NR1I2 (nuclear receptor subfamily 1 group I member 2) is targeted by 259 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NR1I2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Ethinyl Estradiol	2.08	7
2	oxatomide [Supplementary Concept] structure;	2.08	7
3	Clotrimazole	1.95	6
4	Fulvestrant	1.95	6
5	Nisoldipine	1.95	6
6	Reserpine	1.95	6
7	Rifaximin	1.95	6
8	Apigenin 5,7,4'-trihydroxy-flavone,	1.79	5
9	Genistein	1.79	5
10	Resveratrol	1.79	5
11	Vitamin	1.79	5
12	Colchicine	1.79	5
13	Danazol	1.79	5
14	Fluorometholone	1.79	5
15	Loratadine	1.79	5
16	Lovastatin	1.79	5
17	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	1.79	5
18	Bosentan	1.61	4
19	Celecoxib	1.61	4
20	Estrone	1.61	4
21	Fluocinolone Acetonide	1.61	4
22	Flutamide	1.61	4
23	Lithocholic Acid	1.61	4
24	Loteprednol Etabonate	1.61	4
25	Medroxyprogesterone Acetate	1.61	4
26	Phenylbutazone	1.61	4
27	Toxaphene	1.61	4
28	Troglitazone	1.61	4
29	Budesonide	1.39	3
30	Pueraria	1.39	3
31	Kaempferols	1.39	3
32	Vitamin K 2	1.39	3
33	17-alpha-Hydroxyprogesterone	1.39	3
34	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.39	3
35	alpha-Linolenic Acid	1.39	3
36	Beclomethasone	1.39	3
37	Bromodeoxyuridine	1.39	3
38	candesartan cilexetil [Supplementary Concept]	1.39	3
39	Carboxin	1.39	3
40	Demecolcine	1.39	3
41	Desoximetasone	1.39	3
42	Disulfiram	1.39	3
43	Ethylestrenol	1.39	3
44	Gestrinone	1.39	3
45	Halcinonide	1.39	3
46	Leflunomide	1.39	3
47	Levonorgestrel	1.39	3
48	methoprene	1.39	3
49	Methylprednisolone	1.39	3
50	Mometasone Furoate	1.39	3

Showing top 50 of 259 compounds. Use the BiohacksAI search to explore all NR1I2 modulators.

About NR1I2 as a Drug Target

NR1I2 (nuclear receptor subfamily 1 group I member 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 259 compounds with documented NR1I2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NR1I2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.