What compounds target RPS6KA3?

BiohacksAI has identified 36 compounds that interact with RPS6KA3 (ribosomal protein S6 kinase A3). Top compounds include: alvocidib, tozasertib, bosutinib, quizartinib, midostaurin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RPS6KA3 (ribosomal protein S6)?

RPS6KA3 is ribosomal protein S6 kinase A3. It is a molecular target for 36 compounds documented in PubMed bioassay data. UniProt ID: P51812. NCBI Gene ID: 6197.

RPS6KA3

MOLECULAR TARGET

ribosomal protein S6 kinase A3

UniProt: P51812 NCBI Gene: 619736 compounds

RPS6KA3 (ribosomal protein S6 kinase A3) is targeted by 36 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RPS6KA3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	tozasertib	4.33	75
3	bosutinib	4.08	58
4	quizartinib	3.99	53
5	midostaurin	3.85	46
6	molibresib	3.81	44
7	brigatinib	3.81	44
8	eriodictyol	3.76	42
9	lapachol	3.76	42
10	nintedanib	3.61	36
11	tae 684	3.43	30
12	fedratinib	3.40	29
13	gilteritinib	3.40	29
14	bisindolylmaleimide ix	3.14	22
15	dovitinib	3.09	21
16	at 9283	3.09	21
17	upadacitinib	3.09	21
18	lestaurtinib	3.04	20
19	pf 03758309	3.00	19
20	ruboxistaurin	2.94	18
21	r 406	2.83	16
22	k 252a	2.83	16
23	pha 665752	2.71	14
24	kw 2449	2.64	13
25	gsk 461364	2.40	10
26	su 014813	2.20	8
27	enzastaurin	2.08	7
28	cerdulatinib	1.95	6
29	sra 737	1.95	6
30	pf 03814735	1.79	5
31	hydroxyfasudil [Supplementary Concept]	1.39	3
32	fisetin	0.69	1
33	Kaempferols	0.69	1
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
35	pictilisib	0.69	1
36	sp600125	0.69	1

About RPS6KA3 as a Drug Target

RPS6KA3 (ribosomal protein S6 kinase A3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 36 compounds with documented RPS6KA3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RPS6KA3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.