What compounds target TOP1P1?

BiohacksAI has identified 37 compounds that interact with TOP1P1 (DNA topoisomerase I pseudogene 1). Top compounds include: Bortezomib, cycloheximide, Doxycycline, Methylene Blue, Azacitidine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TOP1P1 (DNA topoisomerase I)?

TOP1P1 is DNA topoisomerase I pseudogene 1. It is a molecular target for 37 compounds documented in PubMed bioassay data. NCBI Gene ID: 7151.

TOP1P1

MOLECULAR TARGET

DNA topoisomerase I pseudogene 1

NCBI Gene: 715137 compounds

TOP1P1 (DNA topoisomerase I pseudogene 1) is targeted by 37 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TOP1P1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Bortezomib	1.10	2
2	cycloheximide	1.10	2
3	Doxycycline	0.69	1
4	Methylene Blue	0.69	1
5	Azacitidine	0.69	1
6	Azacitidine	0.69	1
7	Camptothecin	0.69	1
8	celastrol	0.69	1
9	Chlorhexidine	0.69	1
10	clofilium tosylate	0.69	1
11	Colchicine	0.69	1
12	Dactinomycin	0.69	1
13	Dasatinib	0.69	1
14	Daunorubicin	0.69	1
15	Demeclocycline	0.69	1
16	Deslanoside Deacetyllanatoside C.	0.69	1
17	Disulfiram	0.69	1
18	Emetine	0.69	1
19	Ethidium	0.69	1
20	Flecainide	0.69	1
21	Hydroxyurea	0.69	1
22	Ku 0063794 [Supplementary Concept]	0.69	1
23	monorden	0.69	1
24	Niclosamide	0.69	1
25	Noscapine	0.69	1
26	Ondansetron	0.69	1
27	Oxyphenbutazone	0.69	1
28	Puromycin	0.69	1
29	Reserpine	0.69	1
30	Rotenone	0.69	1
31	Sulfadoxine	0.69	1
32	Tetracycline	0.69	1
33	Thapsigargin	0.69	1
34	Tinidazole	0.69	1
35	Topotecan	0.69	1
36	Tripterygium	0.69	1
37	withaferin	0.69	1

About TOP1P1 as a Drug Target

TOP1P1 (DNA topoisomerase I pseudogene 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 37 compounds with documented TOP1P1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TOP1P1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.