BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/TOP2A/Compounds

Compounds That Target TOP2A

DNA topoisomerase II alpha · 147 compounds in BiohacksAI corpus

TOP2A (DNA topoisomerase II alpha) is a biological target with 147 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into TOP2A modulation for therapeutic and biohacking applications.

View TOP2A target page →UniProt: P11388 ↗
Most Studied Compounds for TOP2A
1
Allium Sativum
500+
studies
2
Curcuma Longa
500+
studies
3
Foeniculum Vulgare
499+
studies
4
Centella Asiatica
499+
studies
5
Ethidium Bromide
300+
studies
6
Genistein
300+
studies
7
Topotecan
300+
studies
8
Quercetin
300+
studies
9
Epirubicin
300+
studies
10
Digitoxin
300+
studies
All 57 Compounds — Ranked by Evidence
1
Doxorubicin Hydrochloride
5.71
confidence
2
Elliptecine
5.21
confidence
3
Amsacrine
4.82
confidence
4
Betulin
4.25
confidence
5
Lupeol
4.03
confidence
6
Hoechst 33258
3.09
confidence
7
Hymenialdisine
3.00
confidence
8
Decernotinib
2.20
confidence
9
Ungeremine
2.20
confidence
10
Ganoderiol F
2.08
confidence
11
Merbarone
2.08
confidence
12
Myricetinflavonoids
1.61
confidence
13
Daunorubicin
298+
studies
1.61
confidence
14
Ethidium Bromide
300+
studies
1.10
confidence
15
Genistein
300+
studies
1.10
confidence
16
Topotecan
300+
studies
1.10
confidence
17
Teniposide
299+
studies
1.10
confidence
18
Quercetin
300+
studies
1.10
confidence
19
Foeniculum Vulgare
499+
studies
1.00
confidence
20
Cuscuta Chinensis
1.00
confidence
21
Cynomorium Songaricum
1.00
confidence
22
Dimocarpus Longan
1.00
confidence
23
Ephedra Sinica
1.00
confidence
24
Epimedium Brevicornum
1.00
confidence
25
Eriobotrya Japonica
1.00
confidence
26
Eucommia Ulmoides
1.00
confidence
27
Achyranthes Bidentata
1.00
confidence
28
Agastache Rugosa
1.00
confidence
29
Allium Sativum
500+
studies
1.00
confidence
30
Allium Tuberosum
1.00
confidence
31
Aloe Vera
1.00
confidence
32
Anemarrhena Asphodeloides
1.00
confidence
33
Apis Mellifera
1.00
confidence
34
Arctium Lappa
1.00
confidence
35
Areca Catechu
199+
studies
1.00
confidence
36
Artemisia Annua
1.00
confidence
37
Artemisia Argyi
1.00
confidence
38
Artemisia Capillaris
1.00
confidence
39
Aster Tataricus
1.00
confidence
40
Atractylodes Macrocephala
1.00
confidence
41
Bletilla Striata
1.00
confidence
42
Bombyx Mori
1.00
confidence
43
Bupleurum Chinense
1.00
confidence
44
Carthamus Tinctorius
1.00
confidence
45
Centella Asiatica
499+
studies
1.00
confidence
46
Chaenomeles Speciosa
1.00
confidence
47
Citrus Reticulata
1.00
confidence
48
Crataegus Pinnatifida
1.00
confidence
49
Curculigo Orchioides
116+
studies
1.00
confidence
50
Curcuma Longa
500+
studies
1.00
confidence
51
Idarubicin
299+
studies
0.69
confidence
52
Epirubicin
300+
studies
0.69
confidence
53
Digitoxin
300+
studies
0.69
confidence
54
Dexrazoxane
298+
studies
0.69
confidence
55
Aclarubicin
300+
studies
0.69
confidence
56
Fisetin
78+
studies
0.69
confidence
57
Ciprofloxacin
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for TOP2A (DNA topoisomerase II alpha). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: TOP2A target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.