BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Targets/TOP2A
MOLECULAR TARGETUniProt: P11388

TOP2A

DNA topoisomerase II alpha

147 compounds · BiohacksAI corpus v20260307-01

147
compounds
Compounds
147
Gene Symbol
TOP2A
NCBI Gene
7153

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About TOP2A

TOP2A (DNA topoisomerase II alpha) is a biological target studied in biomedical research. The BiohacksAI corpus identifies 147 compounds with documented interactions with this target, based on BindingDB assay data and PubMed literature.

View TOP2A on UniProt →
Compounds Targeting TOP2A (50)
1
Doxorubicin Hydrochloride
5.71
confidence
2
Elliptecine
5.21
confidence
3
Amsacrine
4.82
confidence
4
Betulin
4.25
confidence
5
Lupeol
4.03
confidence
6
Hoechst 33258
3.09
confidence
7
Hymenialdisine
3.00
confidence
8
Decernotinib
2.20
confidence
9
Ungeremine
2.20
confidence
10
Ganoderiol F
2.08
confidence
11
Merbarone
2.08
confidence
12
Myricetinflavonoids
0
studies
1.61
confidence
13
Daunorubicin
298
studies
1.61
confidence
14
Ethidium Bromide
300
studies
1.10
confidence
15
Genistein
300
studies
1.10
confidence
16
Topotecan
300
studies
1.10
confidence
17
Teniposide
299
studies
1.10
confidence
18
Quercetin
300
studies
1.10
confidence
19
Foeniculum Vulgare
499
studies
1.00
confidence
20
Cuscuta Chinensis
1.00
confidence
21
Cynomorium Songaricum
1.00
confidence
22
Dimocarpus Longan
1.00
confidence
23
Ephedra Sinica
1.00
confidence
24
Epimedium Brevicornum
1.00
confidence
25
Eriobotrya Japonica
1.00
confidence
26
Eucommia Ulmoides
1.00
confidence
27
Achyranthes Bidentata
1.00
confidence
28
Agastache Rugosa
1.00
confidence
29
Allium Sativum
500
studies
1.00
confidence
30
Allium Tuberosum
1.00
confidence
31
Aloe Vera
1.00
confidence
32
Anemarrhena Asphodeloides
1.00
confidence
33
Apis Mellifera
1.00
confidence
34
Arctium Lappa
1.00
confidence
35
Areca Catechu
199
studies
1.00
confidence
36
Artemisia Annua
1.00
confidence
37
Artemisia Argyi
1.00
confidence
38
Artemisia Capillaris
1.00
confidence
39
Aster Tataricus
1.00
confidence
40
Atractylodes Macrocephala
1.00
confidence
41
Bletilla Striata
1.00
confidence
42
Bombyx Mori
1.00
confidence
43
Bupleurum Chinense
1.00
confidence
44
Carthamus Tinctorius
1.00
confidence
45
Centella Asiatica
499
studies
1.00
confidence
46
Chaenomeles Speciosa
1.00
confidence
47
Citrus Reticulata
1.00
confidence
48
Crataegus Pinnatifida
1.00
confidence
49
Curculigo Orchioides
116
studies
1.00
confidence
50
Curcuma Longa
500
studies
1.00
confidence
Top 50 compounds by confidence score. Derived from BindingDB assay data.
Data Source
Corpusv20260307-01
SourceBindingDB · ChEMBL · PubMed

All data is computationally derived from published research. Not medical advice. Independent validation required.