What compounds affect the PLC beta mediated events pathway?

102 compounds in the BiohacksAI corpus have documented interactions with genes in the PLC beta mediated events pathway (Reactome ID: R-HSA-112043). These compounds target 17 genes within this pathway.

What genes are in the PLC beta mediated events pathway?

The PLC beta mediated events pathway involves 17 genes. Key genes include: ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1, GNA15, GRK2, MAPK1, PDE1A.

PLC beta mediated events

REACTOME PATHWAY

Reactome: R-HSA-11204317 genes102 compounds

The PLC beta mediated events pathway (Reactome ID: R-HSA-112043) involves 17 genes and is affected by 102 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1 GNA15 GRK2 MAPK1 PDE1A PDE1B PDE1C PLCB3 PRKACA PRKACB PRKACG PRKX

Compounds Affecting PLC beta mediated events

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	hydroxyfasudil [Supplementary Concept]	—	11
3	vinpocetine	—	299
4	Papaverine	—	299
5	Disulfiram	—	297
6	trequinsin hydrochloride	—	1
7	Quercetin	—	300
8	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
9	alsterpaullone	—	12
10	Calcimycin	—	216
11	Sorafenib	—	300
12	Aurintricarboxylic Acid	—	184
13	Cefixime	—	300
14	Sphingosine	—	300
15	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
16	Axitinib	—	298
17	cycloheximide	—	300
18	Azacitidine	—	298
19	Azacitidine	—	300
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Levalbuterol	—	1,000
22	Adenosine Monophosphate Adenine nucleotide containing	—	300
23	Levalbuterol	—	297
24	Bortezomib	—	300
25	Clofarabine	—	298
26	Dactinomycin	—	297
27	Danazol	—	298
28	Emetine	—	298
29	Ethidium	—	300
30	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
31	Sulbactam	—	299
32	chrysin	—	300
33	Genistein	—	300
34	Testosterone	—	299
35	Ciclopirox	—	88
36	Cladribine	—	297
37	Clenbuterol	—	300
38	Corticosterone	—	300
39	Dasatinib	—	299
40	Daunorubicin	—	298
41	Dinoprostone	—	296
42	Epinephrine	—	299
43	Ethinyl Estradiol	—	300
44	Imatinib Mesylate	—	300
45	Nisoldipine	—	297
46	Nocodazole Nocodazole is	—	215
47	Masoprocol	—	300
48	Norepinephrine Precursor of epinephrine that is secreted by	—	298
49	o-Phthalaldehyde	—	300
50	Oxyphenbutazone	—	300

About the PLC beta mediated events Pathway

The PLC beta mediated events pathway is catalogued in Reactome (ID: R-HSA-112043) and involves 17 genes. In the BiohacksAI corpus, 102 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK2B, CAMK2D, CAMKK1, CAMKK2.