What compounds affect the Activation of NF-kappaB in B cells pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of NF-kappaB in B cells pathway (Reactome ID: R-HSA-1169091). These compounds target 39 genes within this pathway.

What genes are in the Activation of NF-kappaB in B cells pathway?

The Activation of NF-kappaB in B cells pathway involves 39 genes. Key genes include: ADRM1, CHUK, CUL1, IKBKB, MAP3K7, NFKB1, NFKBIA, PSMA1, PSMA2, PSMA3.

Activation of NF-kappaB in B cells

REACTOME PATHWAY

Reactome: R-HSA-116909139 genes58 compounds

The Activation of NF-kappaB in B cells pathway (Reactome ID: R-HSA-1169091) involves 39 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 IKBKB MAP3K7 NFKB1 NFKBIA PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+9 more

Compounds Affecting Activation of NF-kappaB in B cells

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	chicoric acid	—	117
4	Quercetin	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Resveratrol	—	298
8	Podophyllotoxin	—	14
9	egcg	—	300
10	Kaempferols	—	300
11	Rutin	—	300
12	Withania	—	500
13	Disulfiram	—	297
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	tamarixetin	—	26
16	Trifluridine	—	295
17	withaferin	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Crizotinib	—	298
20	Hydrocortisone	—	299
21	Cerulenin	—	300
22	Chlorpropamide	—	300
23	daph	—	2
24	Hexachlorophene	—	300
25	Hydrocortisone	—	298
26	Lovastatin	—	300
27	ly294002	—	11
28	Promethazine	—	121
29	protriptyline	—	296
30	streptonigrin	—	299
31	Sulfaphenazole	—	300
32	Triamcinolone	—	300
33	tyrphostin 1	—	1
34	tyrphostin ag 1478	—	4
35	Voriconazole	—	299
36	Cathelicidins Antimicrobial cationic peptides with	—	300
37	plumbagin [Supplementary Concept]	—	300
38	Ursolic Acid	—	300
39	Oleanolic Acid	—	300
40	pyrrolidine dithiocarbamate	—	275
41	vinblastine sulfate	—	81
42	4-Hydroxybenzoate-3-Monooxygenase	—	300
43	chrysin	—	300
44	Genistein	—	300
45	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
46	Sorafenib	—	300
47	Adenosine	—	298
48	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
49	Adenosine Triphosphate	—	300
50	alsterpaullone	—	12

About the Activation of NF-kappaB in B cells Pathway

The Activation of NF-kappaB in B cells pathway is catalogued in Reactome (ID: R-HSA-1169091) and involves 39 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, IKBKB, MAP3K7.