What compounds affect the Signaling by TGF-beta Receptor Complex pathway?

134 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by TGF-beta Receptor Complex pathway (Reactome ID: R-HSA-170834). These compounds target 30 genes within this pathway.

What genes are in the Signaling by TGF-beta Receptor Complex pathway?

The Signaling by TGF-beta Receptor Complex pathway involves 30 genes. Key genes include: CCNC, CCNT2, CDK8, CDK9, EP300, FKBP1A, FURIN, HDAC1, ITGAV, ITGB3.

Signaling by TGF-beta Receptor Complex

REACTOME PATHWAY

Reactome: R-HSA-17083430 genes134 compounds

The Signaling by TGF-beta Receptor Complex pathway (Reactome ID: R-HSA-170834) involves 30 genes and is affected by 134 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNC CCNT2 CDK8 CDK9 EP300 FKBP1A FURIN HDAC1 ITGAV ITGB3 MAPK1 MAPK3 MEN1 MYC NCOR1 NCOR2 NEDD8 PARP1 PPP1CA PPP1CC PRKCZ SERPINE1 SMAD2 SMAD3 STAT1 TGFBR1 TGFBR2 UBE2M UCHL5 XPO1

Compounds Affecting Signaling by TGF-beta Receptor Complex

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	egcg	—	300
3	Sorafenib	—	300
4	kenpaullone	—	8
5	Dasatinib	—	299
6	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
7	Bortezomib	—	300
8	Daunorubicin	—	298
9	Hexachlorophene	—	300
10	plumbagin [Supplementary Concept]	—	300
11	Calcimycin	—	216
12	cycloheximide	—	300
13	Danazol	—	298
14	Loratadine	—	296
15	Podophyllotoxin	—	14
16	Celecoxib	—	295
17	Nocodazole Nocodazole is	—	215
18	streptonigrin	—	299
19	trequinsin hydrochloride	—	1
20	Vorinostat	—	299
21	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
22	Azacitidine	—	298
23	Azacitidine	—	300
24	Disulfiram	—	297
25	Nisoldipine	—	297
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Kaempferols	—	300
28	Quercetin	—	300
29	Colchicine	—	300
30	Dactinomycin	—	297
31	Dinitrochlorobenzene	—	300
32	Ethidium	—	300
33	Flutamide	—	298
34	Oxyphenbutazone	—	300
35	vinblastine sulfate	—	81
36	Vincristine	—	299
37	chrysin	—	300
38	Fluoxetine	—	1,000
39	Methylene Blue	—	200
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Ciclopirox	—	88
42	Cladribine	—	297
43	Domperidone	—	299
44	Emetine	—	298
45	Equilin	—	216
46	Ethinyl Estradiol	—	300
47	Ezetimibe	—	296
48	Fluspirilene	—	74
49	Idazoxan	—	300
50	Lynestrenol	—	299

About the Signaling by TGF-beta Receptor Complex Pathway

The Signaling by TGF-beta Receptor Complex pathway is catalogued in Reactome (ID: R-HSA-170834) and involves 30 genes. In the BiohacksAI corpus, 134 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNC, CCNT2, CDK8, CDK9, EP300.