What genes are in the APC/C-mediated degradation of cell cycle proteins pathway?

The APC/C-mediated degradation of cell cycle proteins pathway involves 41 genes. Key genes include: ADRM1, AURKA, AURKB, CCNA1, CCNB1, CDK1, CDK2, CUL1, NEK2, PLK1.

APC/C-mediated degradation of cell cycle proteins

Q: What compounds affect the APC/C-mediated degradation of cell cycle proteins pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the APC/C-mediated degradation of cell cycle proteins pathway (Reactome ID: R-HSA-174143). These compounds target 41 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-17414341 genes52 compounds

The APC/C-mediated degradation of cell cycle proteins pathway (Reactome ID: R-HSA-174143) involves 41 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AURKA AURKB CCNA1 CCNB1 CDK1 CDK2 CUL1 NEK2 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+11 more

Compounds Affecting APC/C-mediated degradation of cell cycle proteins

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	kenpaullone	—	8
5	Quercetin	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	alsterpaullone	—	12
9	Sorafenib	—	300
10	fisetin	—	78
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	chrysin	—	300
13	Axitinib	—	298
14	Crizotinib	—	298
15	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
16	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
17	indirubin	—	300
18	Disulfiram	—	297
19	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
20	Kaempferols	—	300
21	Dasatinib	—	299
22	hydroxyfasudil [Supplementary Concept]	—	11
23	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
24	scutellarein	—	113
25	tamarixetin	—	26
26	Clofibrate	—	299
27	Fenofibrate	—	297
28	Sertraline	—	1,000
29	Cinnarizine	—	299
30	Clotrimazole	—	296
31	Rotenone	—	300
32	ly294002	—	11
33	Wortmannin	—	300
34	Oleic Acid	—	112
35	Simvastatin	—	1,000
36	cefaclor	—	299
37	Hexachlorophene	—	300
38	Lithocholic Acid	—	300
39	Nisoldipine	—	297
40	Oxyphenbutazone	—	300
41	Oxytetracycline	—	300
42	4-Hydroxybenzoate-3-Monooxygenase	—	300
43	egcg	—	300
44	Genistein	—	300
45	Aurintricarboxylic Acid	—	184
46	Methylergonovine	—	14
47	Vemurafenib	—	298
48	candesartan cilexetil [Supplementary Concept]	—	300
49	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
50	ninhydrin	—	300

About the APC/C-mediated degradation of cell cycle proteins Pathway

The APC/C-mediated degradation of cell cycle proteins pathway is catalogued in Reactome (ID: R-HSA-174143) and involves 41 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKA, AURKB, CCNA1, CCNB1.