What compounds affect the DARPP-32 events pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the DARPP-32 events pathway (Reactome ID: R-HSA-180024). These compounds target 10 genes within this pathway.

What genes are in the DARPP-32 events pathway?

The DARPP-32 events pathway involves 10 genes. Key genes include: CDK5, PDE4A, PDE4B, PDE4C, PDE4D, PPP1CA, PPP2CA, PRKACA, PRKACB, PRKACG.

DARPP-32 events

REACTOME PATHWAY

Reactome: R-HSA-18002410 genes68 compounds

The DARPP-32 events pathway (Reactome ID: R-HSA-180024) involves 10 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 PDE4A PDE4B PDE4C PDE4D PPP1CA PPP2CA PRKACA PRKACB PRKACG

Compounds Affecting DARPP-32 events

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Papaverine	—	299
3	Thyroxine	—	994
4	Thyroxine	—	300
5	Troglitazone	—	299
6	Enoximone	—	300
7	8-Bromo Cyclic Adenosine Monophosphate	—	101
8	Anthralin	—	299
9	Hexachlorophene	—	300
10	streptonigrin	—	299
11	vinpocetine	—	299
12	Abacavir	—	295
13	Adenosine Triphosphate	—	300
14	Amoxapine	—	259
15	Antazoline	—	229
16	Bromocriptine	—	299
17	Bucladesine	—	31
18	candesartan cilexetil [Supplementary Concept]	—	300
19	Cladribine	—	297
20	Clofarabine	—	298
21	Codeine	—	295
22	Crizotinib	—	298
23	Dextrothyroxine	—	134
24	Dihydroergotamine	—	299
25	Domperidone	—	299
26	Gestrinone	—	221
27	hydrocodone	—	294
28	Moricizine	—	162
29	Nortriptyline	—	295
30	Olmesartan Medoxomil	—	300
31	Terlipressin	—	300
32	palmidrol [Supplementary Concept]	—	300
33	Vitamin K 2	—	300
34	Bufexamac	—	137
35	Cimetidine	—	299
36	Daptomycin	—	298
37	Dequalinium	—	136
38	Disulfiram	—	297
39	Ertapenem	—	299
40	Ethynodiol Diacetate	—	300
41	Methoxsalen	—	300
42	Sulfisomidine	—	73
43	Mometasone Furoate	—	292
44	Oxytetracycline	—	300
45	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
46	Aurintricarboxylic Acid	—	184
47	Calcimycin	—	216
48	Chlorhexidine	—	299
49	Clotrimazole	—	296
50	Fluspirilene	—	74

About the DARPP-32 events Pathway

The DARPP-32 events pathway is catalogued in Reactome (ID: R-HSA-180024) and involves 10 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, PDE4A, PDE4B, PDE4C, PDE4D.